Regulation of low-voltage activated T-type Ca2+ channel activity by kinases and heterotrimeric G-proteins and their roles in physiological responses.
Mechanisms of neuromodulation in central neurons
Circuit mechanisms of sleep and epilepsy
Molecular mechanisms linking inflammation and insulin signaling to control cell growth and metabolism
Epigenetic and genetic mechanisms underlying metabolic disease
Calcium-dependent, membrane-binding proteins and mechanisms of exocytosis
Electrical signals in inflammation and immunity
Sphingolipids in ocular disease and cancer
Cell signaling of protein kinases in development and disease
Neural control of blood pressure and respiration
Molecular mechanisms controlling insulin signaling and fat synthesis.
Investigating the origin of insulin resistance in skeletal muscle and adipose tissue
Nanotechnologies for targeted drug delivery
The mechanism of action of small molecules and the fundamental biological role of protein tyrosine phosphatases
Role of lipid oxidation products in inflammation and vascular immunology in atherosclerosis and diabetes
Chemical biology of sphingosine 1-phosphate
Investigating the role of B cells in aortic aneurysm
Exploring epilepsy circuits then preventing seizures using AAV-based gene therapies.
Immunological mechanisms of acute kidney injury and progressive kidney disease
Regulation of transcription by nuclear hormone receptors, transcriptional control of metabolism, atherosclerosis, Small molecule approaches to drug discovery
Investigation of the neuronal circuits and epigenetic modifications involved in the control of food and drug reward
Exploiting chemical biology approaches to understand signaling pathways that are critical for parasite, neuronal and tumor cell viability
Role of endogenous peptides in control of cardiorespiratory function
Neural Circuits in Healthy and Diseased Brains