Edward Perez-Reyes

Perez-Reyes, Edward

Primary Appointment

Professor, Pharmacology


  • BA, Chemistry, University of North Carolina
  • PhD, Pharmacology, University of Colorado, Denver
  • Research Fellowship, Electrophysiology, Stanford University

Contact Information

PO Box 800735
1340 Jefferson Park Ave., Pinn Hall, Room 5056A
Charlottesville, VA 22908
Telephone: 434-982-4440
Fax: 434-982-3878
Email: ebp8n@virginia.edu
Website: http://people.virginia.edu/~ebp8n/

Research Disciplines

Biophysics, Molecular Pharmacology, Neuroscience, Translational Science

Research Interests

Exploring epilepsy circuits then preventing seizures using AAV-based gene therapies.

Research Description

Current work in the lab is focused on developing gene therapies for pharmacoresistant epilepsies. In these projects we are leveraging our experience in molecular cloning to develop novel adeno-associated viral (AAV) targeting vectors capable of delivering either short-hairpinned RNAs (shRNAs) or genes of interest. Figure below shows drug-inducible delivery of two genes from a single adeno-associated virus in the brain (GFP and mCherry). In a project funded by a CURE Challenge Award, we validated the ability of a modified K+ leak channel to reduce status epilepticus (Epilepsia: PMID: 24299204). In a second project recently funded by NINDS, we are testing the ability of an shRNA directed against the sodium channel subunits to reduce seizures. Both projects are made possible by collaborations with local epilepsy experts, including Jaideep Kapur, John Williamson, Edward Bertram, Mark Beenhakker, and Manoj Patel.

Selected Publications