- BA, Chemistry, University of North Carolina
- PhD, Pharmacology, University of Colorado, Denver
- Research Fellowship, Electrophysiology, Stanford University
Biophysics, Molecular Pharmacology, Neuroscience, Translational Science
Exploring epilepsy circuits then preventing seizures using AAV-based gene therapies.
Current work in the lab is focused on developing gene therapies for pharmacoresistant epilepsies. In these projects we are leveraging our experience in molecular cloning to develop novel adeno-associated viral (AAV) targeting vectors capable of delivering either short-hairpinned RNAs (shRNAs) or genes of interest. Figure below shows drug-inducible delivery of two genes from a single adeno-associated virus in the brain (GFP and mCherry). In a project funded by a CURE Challenge Award, we validated the ability of a modified K+ leak channel to reduce status epilepticus (Epilepsia: PMID: 24299204). In a second project recently funded by NINDS, we are testing the ability of an shRNA directed against the sodium channel subunits to reduce seizures. Both projects are made possible by collaborations with local epilepsy experts, including Jaideep Kapur, John Williamson, Edward Bertram, Mark Beenhakker, and Manoj Patel.