Department of Pharmacology

Pharmacology is a broad and integrative discipline that focuses on the interaction of living cells with the regulatory molecules in their environment. It is a diverse science that proves basic mechanisms of molecular and cellular function with the knowledge that unraveling these mechanisms will lead to new therapeutic approaches to a variety of diseases. The Department of Pharmacology has a unique role within the basic biomedical sciences: to conduct investigations into the fundamental principles of cell function and translate these findings to clinical applications.

Our faculty offer a variety of exciting research opportunities in Cellular and Molecular Pharmacology, including the following Research Interests:

 

Dorian Rosen and Alban Gaultier

Fundamental science can find real world application in unexpected – and important – ways.

Dr. Dorian Rosen (Pharmacology PhD, 2019), while working in the Alban Gaultier lab, showed that a common SSRI antidepressant, fluvoxamine, can also engage the sigma-1 receptor to dampen cytokine-mediate inflammatory responses, likely by effects on ER stress pathways. Based in part on these findings, and recognizing that excess cytokine production may be involved in the progression of COVID-19, researchers at Washington University initiated a small clinical trial that yielded early encouraging results. Now, as reported today in the Lancet, and highlighted in the New York Times, fluvoxamine was found to improve outcomes in high-risk patients with COVID-19 in a large randomized, placebo-controlled trial out of Brazil.
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Philip Seegren

Kudos go out to Philip Seegren: Recipient of the 2021Rall Award!

Congratulations to Philip Seegren for being the recipient of the 2021 Ted W. Rall Award for the best paper by a Pharmacology Student published in the calendar year. He received this award for his first-authored manuscript, “Mitochondrial Ca2+ signaling is an electrometabolic switch to fuel phagosome killing”, published in Cell Reports. Philip is a trainee in Bimal Desai’s Lab and describes the published work and findings of he and his colleges below:
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KeViRx Logo

Kudos to Drs. Lazo and Sharlow: KeViRx Awarded Second NIH R43 Grant

KeViRx is an early stage drug discovery company spun out of the UVA Department of Pharmacology by Elizabeth Sharlow and John Lazo and located in Charlottesville. KeViRx was just awarded its second National Institutes of Health R43 Phase 1 Small Business Innovation Research (SBIR) grant. This grant (HL158409) is entitled “A PTP4A3 inhibitor for SARS-CoV-2-mediated acute lung injury”. The Severe Acute Respiratory Syndrome coronavirus (SARS-CoV-2) is responsible for the current COVID-19 pandemic. Many COVID-19 patients develop acute respiratory distress syndrome (ARDS) and subsequently septic shock and multi-organ failure; about half will die.
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News All News »

Fundamental science can find real world application in unexpected – and important – ways.

Dr. Dorian Rosen (Pharmacology PhD, 2019), while working in the Alban Gaultier lab, showed that a common SSRI antidepressant, fluvoxamine, can also engage the sigma-1 receptor to dampen cytokine-mediate inflammatory…

Kudos go out to Philip Seegren: Recipient of the 2021Rall Award!

Congratulations to Philip Seegren for being the recipient of the 2021 Ted W. Rall Award for the best paper by a Pharmacology Student published in the calendar year. He received…

Kudos to Drs. Lazo and Sharlow: KeViRx Awarded Second NIH R43 Grant

KeViRx is an early stage drug discovery company spun out of the UVA Department of Pharmacology by Elizabeth Sharlow and John Lazo and located in Charlottesville. KeViRx was just awarded…

Kudos to Merci Best: STEAMKITX, a company that makes STEM and Arts kits

The children are definitely our future, and with this in mind, Merci Best (Pharmacology Grad Student in George Bloom's Lab) knows how important it is to keep them interested and…

Seminars All Seminars »

Pharmacology Seminar by Xue Han, PhD

[Pinn 1017] Hosted by Julius Zhu, PhD, Xue Han, PhD, is an Associate Professor of Biomedical Engineering Department College of Engineering and Rajen Kilachand Center for Integrated Life Sciences &Engineering,…
Feb
10

Pharmacology Seminar by David Moore, PhD

[Pinn 1017] Hosted by Irina Bochkis, PhD, David Moore, PhD is a Professor of Molecular Biology at the Nutritional Sciences and Toxicology at UC Berkeley. The Moore laboratory studies the…
Mar
3

Subcellular B Adrenergic Receptor and Phospholipase C Signaling in the Heart by Alan Smrcka, PhD

[Pinn 1017] Hosted by Zheng (John) Fu, PhD, Alan Smrcka, PhD, is a Professor of Biochemistry, Pharmacology, University of Michigan, Ann Arbor, MI The Smrcka Lab studies mechanisms for cellular…
Mar
24

Pharmacology Seminar by Paul Titchenell, PhD

[Pinn 1017] Hosted by Michelle Bland, PhD, Paul Titchenell, PhD, is an Assistant Professor of Physiology, Perelman School of Medicine, Smilow Center for Translational Research, UPenn, Philiadelphia, PA The Titchenell…
Apr
28

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