Seminar Archive

Spring 2022

April 28, 2022|Paul Titchenell, PhD, Assistant Professor of Physiology, Perelman School of Medicine, Smilow Center for Translational Research, UPenn, Philadelphia, PA| TBD| Host: Michelle Bland

April 07, 2022|David Moore, PhD, Professor of Molecular Biology, Nutritional Sciences and Toxicology, UC Berkeley| Control of Liver  Energy Balance by Nutrient Sensing Nuclear Receptors |Host: Irina Bochkis

March 24, 2022|Alan Smrcka, PhD, Professor of Pharmacology University of Michigan Medical School |Subcellular b Adrenergic Receptor and Phospholipase C Signaling in the Heart| Host: John Fu

February 24, 2022|Tarek Abbas, PhD, Associate Professor, Radiation Oncology/Biochemistry and Molecular Biology, University of Virginia |Induction of Large-scale Genomic Amplifications: Mechanisms and Therapeutic Opportunities |Host: Thurl Harris

February 10, 2022|Xue Han, PhD, Associate Professor of Biomedical Engineering Department College of Engineering and Rajen Kilachand Center for Integrated Life Sciences &Engineering, Boston University |Development of Large-scale and High-speed Single Cell Voltage Imaging Tools for Analyzing Biological Neural Networks |Host: Julius Zhu

October 26, 2022|Christopher Mazzone, PhD, Faculty Candidate, Postdoctoral Fellow, Neurobiology Laboratory, National Institute of Environmental Health Sciences (NIEHS) & National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK),  Durham, NC |High-fat Diets Persistently Alter Neural Feeding Circuits |Host: Pharmacology Faculty Search Committee

January 19, 2021|Stephen Abbott, PhD, Faculty Candidate, Assistant Professor of Research, Pharmacology, SOM University of Virginia |Sympathetic Control of Blood Pressure by Brainstem Catecholaminergic Neurons |Host: Pharmacology Faculty Search Committee

January 12, 2022|Edward Nieh, PhD, Faculty Candidate, Postdoctoral Research Associate, Princeton Neuroscience Institute, Princeton, NJ |Population Neural Dynamics in the Hippocampus (and Beyond)| Host: Pharmacology Faculty Search Committee

Fall 2021

November 11, 2021|Joseph Boyle, PhD, Faculty of Medicine, National Heart & Lung Institute, Clinical Reader in Vascular Molecular Pathology, Imperial College London |Macrophages and Hemin Homeostasis in Atherosclerotic |Host: Norbert Leitinger

November 05, 2021|Mitchell A. Lazar, MD, PhD, Willard and Rhoda Ware Professor in Diabetes and Metabolic Diseases Director, Institute for Diabetes, Obesity, and Metabolism |Nuclear Receptors, Circadian Rhythms, and Metabolism-2021 Joseph Larner Memorial Lecture in Pharmacology |Host: Irina Bochkis

October 28, 2021|Philip Niethammer, PhD, Member of Cell Biology, Sloan Kettering Institute, New York, NY |Chemical and Physical Signals of Wound Detection |Host: Bimal Desai

October 07, 2021|David Klorig, PhD, Instructor in the Neurobiology and Anatomy Department, Wake Forest University |Gene Therapy for Epilepsy: Novel Strategies for Rational Design and Evaluation |Host: Ed Perez-Reyes

September 23, 2021|Ilya Levental, PhD, Associate Professor, Molecular Physiology and Biological Physics, University of Virginia |The Composition, Organization and Functions of Mammalian Plasma Membrane| Host: Thurl Harris

Spring 2021

August 19, 2021| Matteo Ottolini, UVA Pharmacology PhD Candidate, Sonkusare Lab | Dissertation Defense: Endothelial TRPV4 channel signaling in blood pressure regulation| Host: Swapnil Sonkusare

June 23, 2021| Adam Borne, UVA Pharmacology PhD Candidate, Hsu Lab | Dissertation Defense: Computational and Chemical Proteomic Strategies for Deconvoluting Inhibitor and Drug Mode of Action| Host: Ken Hsu

April 29, 2021 |Sarah Goetz, PhD, Assistant Professor, Pharmacology & Cancer Biology, Duke University School of Medicine |Building The Cell’s Antenna: Regulation of Cilium Assembly in Development and Disease| Host: Zheng (John) Fu

April 22, 2021 |Chun-Li Zhang, PhD, Professor of Molecular Biology, UT Southwestern Medical Center, Dallas, TX |Cell Fate Reprogramming for Neural Degeneration and Regeneration| Host: Julius Zhu & Mark Beenhakker

March 30, 2021| Adishesh Narahari, UVA Pharmacology PhD Candidate, Bayliss Lab | Dissertation Defense: ATP and Large Signaling Metabolites Flux Through Caspase-activated Pannexin 1 Channels| Host: Douglas Bayliss

March 25, 2021 |Joel Linden, PhD, Professor of Medicine, Nephrology, University of Virginia| Regulation of Insulin Resistance by Adenosine| Host: Kevin Lynch

March 04, 2021 |Yan Dong, PhD, Professor of Neuroscience, University of Pittsburgh| Synaptic Remodeling in Cocaine Memories| Host: Julius Zhu

February 25, 2021 |Noaki Yamanaka, PhD, Assistant Professor of Entomology, University of California, Riverside| Pharmacological Manipulation of Steroid Hormone Entry into Cells| Host: Michelle Bland

February 15, 2021| Brittany Martinez, UVA Pharmacology PhD Candidate, Bland Lab | Dissertation Defense: Innate immune Signaling In Drosophila Melanogaster Shifts Lipid Metabolism To Support Immune Function| Host: Michelle Bland

Fall 2020

November 12, 2020 |Mark Andermann, PhD, Associate Professor of Medicine, Division of Endocrinology, Diabetes and Metabolism, Dept. of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA |Estimation of Current and Future Physiological States in Insular Cortex| Host: Steve Abbott

November 05, 2020 |Polina Anikeeva, PhD, Associate Professor, Materials Science and Engineering, Brain and Cognitive Sciences, MIT| Optical, Electronic, and Magnetic Strategies for Neural Interrogation Across Scales| Host: Julius Zhu & Bimal Desai

October 30, 2020| Katelyn Ahern, UVA Pharmacology PhD Candidate, Harris Lab | Dissertation Defense: Adipocyte Lipolysis and Acute Insulin Resistance| Host: Thurl Harris

October 22, 2020 |Edward Perez-Reyes, PhD,  Professor of Pharmacology, UVA,  Charlottesville, VA| Development of Drug-inducible Gene Therapies for Diabetes| Host: Thurl Harris

October 08, 2020 |Guyenet Lab w/Stephen Abbott, PhD & George Souza, PhD, UVA Pharmacology, Charlottesville, VA| Neural Control of Cardiovascular and Respiratory Function| Host: Steve Abbott

September 24, 2020 |Bland Lab w/Brittany Martinez, UVA Pharmacology, Charlottesville, VA| Innate Immune Control of Growth and Metabolism In Drosophila| Host: Michelle Bland

September 10, 2020 |Bochkis Lab, UVA Pharmacology, Charlottesville, VA| Epigenetics Meets Metabolism |Host: Irina Bochkis

Summer 2020

August 13, 2020 |David Olson, MD, PhD, Assistant Professor, Pediatrics and Communicable Diseases, Medicine, University of Michigan, Ann Arbor, MI|Central Nervous System Control of Energy Balance| Host: Michael Scott

June 30, 2020 |Rita Valentino, PhD, Director, Division of Neuroscience and Behavior,  National Institute on Drug Abuse, Bethesda, MD|Sex, Stress and Coping| Host: John Lazo

July 16, 2020 |Desai Lab w/Marta Stremska, Catherine Doyle, Philip Seegren, UVA Pharmacology, Charlottesville, VA|Ion Channels In Cell-Intrinsic Immunity| Host: Bimal Desai

July 02, 2020 |Bayliss Lab w/Keyong Li, Liz Gonye, and Yingtang Shi, UVA Pharmacology, Charlottesville, VA|RTN Neurons and Respiratory Chemoreception: Channels, Receptors & Peptides| Host: Douglas Bayliss

June 18, 2020 |J. Julius Zhu, PhD, Professor of Pharmacology and Neuroscience, University of Virginia, Charlottesville, VA|Opto-tools| Host: Julius Zhu

June 04, 2020 |W. Dean Harman, PhD, Professor of Chemistry & Brooks H. Pate, PhD, William R. Kenan Jr. Professor of Chemistry, Unversity of Virginia, Charlottesville, VA|Selective Deuteration in Medicines: New Approaches to Synthesis and Analysis| Host: John Lazo & Bimal Desai

Spring 2020

March 26, 2020 |Alan Smrcka, PhD, Professor of Pharmacology, Medical School and Professor of Biophysics, College of Literature Science and Arts, University of Michigan, Ann Arbor MI|Subcellular b Adrenergic Receptor and Phospholipase C Signaling in the Heart| Host: Zheng “John” Fu

February 27, 2020 |Siyuan Rao, PhD, Postdoctoral Fellow (Polina Anikeeva’s Lab), Materials Science and Engineering, BioElectronics, Cambridge, MA|Engineering Platform for Neural Circuit Interrogation| Host: Julius Zhu

Fall 2019

December 11, 2019 |Thiago S Moreira, PhD, Assistant Professor, Physiology and Biophysics, University of Sao Paulo/USP, San Paulo, Brazil|Cholinergic Modulation of Breathing| Host: Patrice Guyenet and Ruth Stornetta

December 05, 2019 |Markus Delling, PhD, Assistant Professor, Physiology, School of Medicine, UCSF, San Francisco, CA|Calcium Signaling in Primary Cilia During Development and Disease| Host: Bimal Desai

November 21, 2019 | Michael Murphy, PhD, Professor of Mitochondrial Redox Biology and Program Director, MRC Mitochondrial Biology Unit, University of Cambridge, UK|The Role of Mitochondrial  ROS Production in Health and Disease-2019 Joseph Larner Memorial Lecture in Pharmacology| Host: Thurl Harris and Michelle Bland

November 07, 2019 | Joseph Bass, PhD, Charles F. Kettering Professor of Medicine, Department of Medicine, Feinburg School of Medicine and Chief of the Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University, Chicago, IL|NAD+ Regulation of Circadian Systems and Aging| Host: Irina Bochkis

October 24, 2019 |Luis de Lecea, PhD, Professor of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Stanford, CA|To Sleep or Not to Sleep: How The Brain Decides To Wake Up| Host: Julius Zhu

September 26, 2019 | Chien Li, PhD, Principal Research Scientist, Novo Nordisk Research Center, Oregon Health and Science University, Seattle, WA|Anti-Obesity Drug Development: The Potential and the Challenge| Host: Michael Scott

September 24, 2019 | Loren Looger, PhD, Janelia Group Leader, Engineering Proteins in the Brain, Janelia Research Campus, VA|Tools for Studying Neural Circuit Function| Host: Julius Zhu; NGP Seminar and Co-sponsored by Pharmacology

September 12, 2019 | Viji Santhajumar, PhD, Associate Professor, Molecular, Cell and Systems Biology, University of California, Riverside, CA|Janus-Faced Effects of TLR4 on Hippocampal Dentate Excitability and Their Long-Term Impact on Network Function After Traumatic Brain Injury| Host: Mark Beenhakker

Spring 2019

May 30, 2019 | Lesley Colgan, PhD, Reseach Fellow, Neuronal Signal Transduction, Max Planck Florida Institute for Neuroscience, Jupiter, FL|Imaging Molecular Activity During Dendritic Spine Plasticity: FRETing Over Protein Kinase C Function| Host: Julius Zhu

May 15, 2019 | Paul Kenny, PhD, Professor and Chair, Neuroscicnce, Icahn School of Medicine at Mount Sinau, New York, NY| Mechanisms by which GLP-1 Signing Controls Nicotine Intake | Host: Julius Zhu

May 09,  2019 | Edmund Talley, PhD, Program Director, Channels Synapses and Circuits, NIH National Institute of Neurological Disorders and Stroke (NINDS), Bethesda, MD | Brain Initiative and Beyond-Neuroscience Funding Priorities from the NIH | Host: Douglas Bayliss, NGP/Neuroscience and the Brain Institute

April 25, 2019 | Nigel Pedersen, PhD, Assistant Professor of Neurology, Emory University,  Atlanta, GA | Neural Circuits in Sleep and Epilepsy| Host: Steve Abbott

April 17, 2019 | Dorian A Rosen, UVA Pharmacology PhD Candidate, Gaultier Lab |Dissertation Defense: Sigma-1 Receptor and the Control of Inflammation | Host: Alban Gaultier

April 11, 2019 | Sayeepriyadarshini “Sayee” Anakk, PhD, Assistant Professor, Molecular and Integrative Physiology,  University of Illinois at Urbana-Champaign, Urbana, IL |Liver Diseases: Bile Acid Signaling Goes Scallywag | Host: Irina Bochkis

March 28, 2019 | Huiping Zhou, PhD, Professor, Microbiology and Immunology, Virginia Commonwealth University,  Richmond, VA | Bile Acids, G protein coupled Receptors and Fatty Liver Diseases | Host: Kevin Lynch

March 18, 2019 | Alex Keller, UVA Pharmacology PhD Candidate, Isakson Lab | Dissertation Defense: Mechanism of Arterial Dilation in Exercise Hyperemia| Host: Brant Isakson

March 15, 2019 | Paul Carlier, Professor, Organic and Medicinal Chemistry, Dept of Chemistry, Virginia Tech University, Blacksburg, VA |Target Validation for Malaria: Case Studies and New Strategies| Host: Beth Sharlow, John Lazo, and 2019 PHAR 9003 Class

March 07, 2019 | Savraj Grewal, PhD, Associate Professor, Biochemistry & Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, CA | TOR Kinase Signaling and the Regulation of Hypoxia Tolerance in Drosophilia | Host: Michelle Bland

February 28, 2019 | Edward Dennis, PhD, Distinguished Professor of Pharmacology and Chemistry & Biochemistry, School of Medicine, University of California, San Diego, CA | Phopholipase A2, Lipidomics, and Lipid Mediators in Inflammation| Host: Ku-Lung (Ken)Hsu

February 14, 2019 | Amy Walker, PhD, Associate Professor, Molecular Medicine, University of Massachusetts Medical School, Worcester, MA | Metabolic Control of Methylation Alters Lipogenesis and Responses to Stress| Host: Thurl Harris

Fall 2018

December 17 2018 | Michael Schappe, UVA Pharmacology PhD Candidate, Desai Lab | Dissertation Defense: Characterization of the Chanzyme TRPM7 in Macrophages| Host: Bimal Desai

November 29, 2018 | Christopher Ford, PhD, Principal Investigator, School of Medicine, University of Colorado, Denver, CO | Encoding Dopamine Signals in Striatal Circuits |
Host: Julius Zhu

November 15, 2018 | Holly A. Ingraham, PhD, Professor and Associate Vice Chair, Cellular and Molecular Pharmacology, Herstein Distinguished Investigator, UCSF, San Francisco, CA|Female Bones and Behaviors Controlled by Sex-Dependent Hypothalamic Nodes-2018 Joseph Larner Memorial Lecture in Pharmacology | Host:  Michelle Bland and Thurl Harris

November 08, 2018 | Ben Turk, PhD, Associate Professor of Pharmacology, School of Medicine, Yale University, New Haven, CT | Deciphering Mechanisms of Substrate Targeting by Protein Kinases | Host: John Fu

October 31, 2018 | Leon DeLalio, UVA Pharmacology PhD Candidate, Isakson Lab | Dissertation Defense: Regulation of Blood Pressure Homeostasis by Pannexin 1 Channels | Host: Brant Isakson

October 25, 2018 | Steven Kliewer, PhD, Professor and Diana K. and Richard C. Strauss Distinguished Chair in Developmental Biology, Molecular Biology and Pharmacology, UT Southwestern Medical Center, Dallas, TX | Metabolic Stress Hormone FGF21: From Thirsty to Thin | Host: Irina Bochkis

October 11, 2018 | Yanhua Huang, PhD, Associate Professor, Psychiatry, University of Pittsburgh, Pittsburgh, PA | Sleep-mediated regulation of Natural and Drug Reward | Host: Julius Zhu

September 26, 2018 | Sergio Grinstein, PhD, Professor, Cell Biology Program, The Hospital for Sick Children and Department of Biochemistry, University of Toronto | Role of Phosophoinositides and the Cytoskeleton in Phagocytosis | Host: Kodi Ravichandran, PhD and Pharmacology Graduate Students

Spring 2018

May 03, 2018 | Bruce Littlefield, PhD Candidate,  Distinguished Scientist and Head, Translational Medicine, Global Oncology, Eisai Inc., Andover, MA| My Accidental Career: Mitosis, Microtubules, Natural Product-Based Cancer Drug Development and Other Stuff That Was Never Part of My Plan | Host: Spring 2018 Pharm 9004 Class, John Lazo and Beth Sharlow

April 26, 2018 | John Huguenard, PhD Professor, Neurology and Neurological Sciences, Stanford University | To Burst or Not to Burst- Roles of Cav3.1 in Epilepsy | Host: Mark Beenhakker

April 19, 2018  | Josh Huang, PhD, Professor, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY| Genetic Dissection of Cortical Neuron Types and Circuits: from Transcriptional Mechanism to Motor Control | Host: Julius Zhu; Co-Sponsored by the Brain Institute

April 17, 2018 | Yiyang Gong, PhD, Associate Professor, Biomedical Engineering, Duke University | Spike Detection with Engineered Optical Voltage Sensors | Host: Julius Zhu; Co-Sponsored by NGP

April 12, 2018 | James Granneman, PhD, Joseph P. and Rose F. Kennedy Professor, Child Neurology and Mental Retardation, Harvard Medical School and Chief, Pediatric Neurology, Massachusetts General Hospital| A New Locus of Lipolysis Control in Adipose Tissue and Muscle | Host: Thurl Harris

March 29, 2018 | Kevin Foskett, PhD, Isaac Ott Professor and Chair,  Physiology, Perelman School of Medicine, University of Pennsylvania | Molecular Regulation and Physiological Role of ER-to-Mitochondrial Ca2+ Transfer | Host: Adi Narahari/Pharm Students

March 28, 2018 | Vlad Serbulea, UVA Pharmacology PhD Candidate, Leitinger’s Lab | Dissertation Defense: Control of Macrophage Metabolism by Oxidized Phosopholipids; Implications in Obesity-associated Adipose Tissue Inflammation | Host: John Lazo

March 22, 2018 | Valentin Cracan, PhD, Instructor of Molecular Biology, Biology Simches Research Center, Massachusetts General Hospital, Boston, MA | Genetically encoded tools for compartment-specific manipulation of NAD+/NADH and NADP+/NADPH in living cells | Host: Bimal Desai

March 20, 2018 | Carrie Jones, PhD, Assistant Professor, Pharmacology, Director of Behavior Pharmacology, Vanderbilt University | Academic Target Validation and Drug Discovery: Development of M5 NAMs for Opioid Use Disorder | Host: Spring 2018 Pharm 9003 Class, John Lazo and Beth Sharlow

March 15, 2018 | Yu Sin Kim, PhD, Assistant Professor, Neuroscience, Cell Biology, & Anatomy | In Vivo Cellular Ca++ Imaging to Study Chronic Pain | Host: Bimal Desai

March 08, 2018 | Heather Ferris, MD, PhD, Assistant Professor of Medicine, Division of Endocrinology and Metabolism Clinical Investigator in Residence, Neuroscience, School of Medicine, University of Virginia | Investigating Brain Metabolism in Health and Disease | Host: Thurl Harris

February 20, 2018 | Kelley McQueeneyUVA Pharmacology PhD Candidate, Lazo Lab| Dissertation Defense: “The Role of PTP4A3 Phosphatase in Microvascular Endothelial and Tumor Cells”| Host: John Lazo

February 6, 2018 | Zachary Knight, PhD, Assistant Professor, Physiology and member of Kavli Institute for Fundamental Neurosciences, University of California, San Francisco | The Neurobiology of  Hunger | Host: Douglas Bayliss; Hosted by NGP and Pharmacology

Fall 2017

December 7, 2017 | Daniel P. Kelly, M.D, PhD, Willard and Rhoda Ware Professor, Director, Penn Cardiovascular Institute, University of Pennsylvania|Fuel Metabolic Checkpoints as Targets for Cardiometabolic Disease-2017 Joseph Larner Memorial Lecture in Pharmacology | Host: Thurl Harris and Michelle Bland

November 30, 2017 | Zhiping Pang, PhD, Assistant Professor and Principal Investigator, Neurosciences and Cell Biology, Child Health Institute of New Jersey, Rutgers-Robert Wood Johnson Medical School | TBD | Host: Mike Scott

November 09, 2017 | Felix Viana, PhD, Co-Director, Sensory Transduction of Nociception Group, Institute of Neuroscience UMH-CSIC, Alicante, Spain| Molecular Physiology of Cold-activated TRP Channels | Host: Douglas Bayliss

November 09, 2017 | Christophe Bernard, PhD, Professor and Director, Physiology & Physiopathology of Neuronal Networks Group(PhysioNet), Institut de Neurosciences des Systemes | The Dynamic Epileptic Brain | Host: Mark Beenhakker

October 26, 2017 | Andrew Duncan, PhD, Assistant Professor, Pathology, University of Pittsburgh | Mechanisms and Function of Polyploidy in the Liver | Host: Michelle Bland

September 14, 2017 | Johnathan Kagan, PhD, Associate Professor, Pediatrics, Harvard Medical School | Initiation and Regulation of Innate Immunity | Host: Bimal Desai

August 31, 2017 | Sheila Collins, PhD, Professor, Integrative Metabolism Program, Center for Metabolic Origins of Disease, Sanford Burnham Prebys Medical Discovery Institute | Signaling Mechanisms Old and New in Adipocyte Metabolism and Energy Expenditure | Host: Thurl Harris

Spring 2017

May 26, 2017 | Sarah Gray, UVA Pharmacology PhD Candidate, Barrett Lab | Dissertation Defense: Unraveling Insulin Transport Across the Brain Endothelium | Host: Eugene Barrett

May 4, 2017 | Sabrina Diano, PhD, Principal Investigator, Professor of Obstetrics, Gynecology, and Reproductive Sciences, of Comparative Medicine and of Neuroscience, Director, Reproductive Neurosciences Group, Yale School of Medicine | Central Control of Peripheral Glucose Metabolism | Host: Michelle Bland

April 27, 2017 | Peter Penzes, PhD, Professor, Physiology and Psychiatry & Behavioral Sciences, Northwestern University Feinberg School of Medicine | Synaptic Functions of Psychiatric Disorder Risk Factors | Host: Julius Zhu

April 20, 2017 | Tona Gilmer, PhD, Co-founder and CSO XRad Therapeutics, Manager, TMGilmer Consulting LLC|A Journey Through Drug Discovery and Development | Host: Elizabeth Sharlow, John Lazo, and Pharm 9004 Spring 2017 class.

April 19, 2017 | Salome Boroda, UVA Pharmacology PhD Candidate, Harris Lab| Dissertation Defense: Repositioning of Ritanserin for the Inhibition of DGK-alpha and the Mechanistic Role of the Polybasic Domain in the Phosphoregulation of Lipins | Host: Thurl Harris

April 13, 2017 | Kevin Staley, MD, Joseph P. and Rose F. Kennedy Professor of Child Neurology and Mental Retardation, Harvard Medical School, and Chief, Pediatric Neurology, Massachusetts General Hospital | Circuit-based Mechanisms, Biomarkers and Treatments of Epilepsy | Hosts: Jaideep Kapur and Mark Beenhakker; Co-sponsored by Neurology

April 6, 2017 | Stephen Liberles, PhD, Associate Professor, Cell Biology, Harvard Medical School | Internal and External Sensory Systems | Host: Bimal Desai

March 30, 2017 | William Zagotta, PhD, Professor of Physiology and Biophysics, University of Washington | Molecular Mechanisms of Gating in Cyclic Nucleotide-Regulated Ion Channels | Host: Adi Narahari/Pharm Students

March 23, 2017 | Haoxing Xu, PhD, Associate Professor of Molecular, Cellular, and Developmental Biology, University of Michigan | Ion Channels of Intracellular Membranes | Host: Bimal Desai

March 21, 2017 | Heidi Gillenwater, PhD, Senior Director, Juno Therapeutics, Inc., Charlottesville, Va. | Stories of Success and Failure in Drug Development | Host: Elizabeth Sharlow, John Lazo and Pharm 9003 Spring 2017 class

March 15, 2017 | Mariusz Ratajczak, Professor, Department of Medicine, University of Louisville School of Medicine | The Novel Role of Complement Cascade and Bioactive Phosophoshingolipids in Trafficking of Hematopoietic Stem Cells | Host: Kevin Lynch

February 23, 2017 | Jürgen Wess, PhD, Senior Investigator, Molecular Signaling Section, Laboratory of Bioorganic Chemistry, NIDDK/NIH | Designer GPCRs as Novel Tools to Identify Pathways Critical for Glucose and Energy Homeostasis | Host: Thurl Harris

February 13, 2017 | Baohua Liu, PhD, HHMI, Neurobiology, University of CA, San Francisco | Adaptive Control of Innate Reflexes by Visual Cortex | Host: Pharmacology Faculty Search Committee

February 6, 2017 | Ping Li, PhD, Dept Biochemistry, Stanford University, CA | The Neuropeptide Control Circuit for Sighing | Host: Pharmacology Faculty Search Committee

January 30, 2017 | Elizabeth Lucas, PhD, Dept Chemical & Biomolecular Engineering, Icahn School of Medicine @ Mount Sinai, NY | Losing Your Inhibition: GABAergic Plasticity in Emotional Learning | Host: Pharmacology Faculty Search Committee

January 26, 2017 | Catherine Marcinkiewcz, PhD, University of North Carolina @ Chapel Hill, NC | Serotonin Circuits in Anxiety and Alcohol Dependence | Host: Pharmacology Faculty Search Committee

January 23, 2017 | Jay Bikoff, PhD, Dept Biochemistry & Molecular Biophysics, Columbia University, NY | Inhibitory Circuits for Limb Motor Control | Host: Pharmacology Faculty Search Committee

January 19, 2017 | Li Ye, PhD, HHMI & Dept of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA | CLARITY-Based Whole Brain Circuits Mapping: From Behavior to Metabolism | Host: Pharmacology Faculty Search Committee

Fall 2016

December 8, 2016 | Anthony Futerman, PhD, Principal Investigator, Department of Biomolecular Sciences, Weizmann Institute of Science, Israel | Simple Sphingolipids; Complex Diseases | Host: Mark Kester

November 10, 2016 | Alyssa Hasty, PhD, Professor, Molecular Physiology and Biophysics, Vanderbilt University School of Medicine | A Role for Resident Macrophages in Adipose Tissue Iron Homeostasis | Host: Norbert Leitinger

October 27, 2016 | Huaxi Xu, PhD, Professor, Degenerative Diseases Program, Sanford Burnham Prebys Medical Discovery Institute, Co-Editor-in-Chief, Molecular Neurodegeneration | Novel Genes and Pathways Contributing to Alzheimer’s and Related Neurodegenerative Diseases | Host: Julius Zhu

October 13, 2016 | Steven Farber, PhD, Carnegie Institution for Science, Department of Embryology | Fishing for Regulators: Live Imaging of Intestinal Lipid Flux Through Lipoproteins and Lipid Droplets Using the Larval Zebrafish | Host: Michelle Bland

October 6, 2016 | Alan Cherrington, PhD, Professor of Molecular Physiology and Biophysics, Jacquelyn A. Turner and Dr. Dorothy J. Turner Chair in Diabetes Research, Vanderbilt University School of Medicine | Control of Hepatic Glucose Uptake and Storage in the Postprandial State – 2016 Joseph Larner Memorial Lecture in Pharmacology | Hosts: Michelle Bland and Thurl Harris

September 22, 2016 | John Catravas, PhD, Professor, Frank Reidy Center for Bioelectrics, Old Dominion University | Regulation of Pulmonary Endothelial Barrier Function by Hsp90 | Host: John Lazo

September 8, 2017 | Laszlo Nagy, MD, PhD, Professor and Director of the Genomic Control of Metabolism Program, Sanford Burnham Prebys Medical Discovery Institute | Defining the Healing Macrophage Phenotype Using Genomic Approaches | Host: Norbert Leitinger

Spring 2016

July 5, 2016 | Zeinab Chitforoushzadeh, Pharmacology PhD Candidate, Kevin Janes’s Lab | University of Virginia Dissertation Defense | GATA6 Crosstalk between Insulin Signaling and Tumor Necrosis Factor Alpha-induced Gene Expression | Host: Kevin Janes

June 2, 2016 | Na Ji, PhD, Group Leader, Janelia Research Campus, HHMI |Probing Neural Circuits with Shaped Light | Host: Lukas Tamm, Co-sponsored by the Department of Molecular Physiology and Biological Physics

May 24, 2016 | Stanley Ching-Cheng Huang, PhD, Postdoctoral Research Scholar, Department of Pathology & Immunology, Washington University School of Medicine | Metabolic Reprogramming in Macrophage Activation |Host: Pharmacology Faculty Search Committee

May 19, 2016 | Jaemin Lee, PhD, Research Fellow, Division of Endocrinology, Boston Children’s Hospital, Harvard Medical School | The Central Role of ER Stress on the Development of Obesity and Type 2 Diabetes | Host: Pharmacology Faculty Search Committee

May 12, 2016 | L. Ashley Cowart, PhD, Associate Professor of Biochemistry and Biology, Medical University of South Carolina | Sphingosine-1-Phosphate: Linking Lipid Signaling to Metabolic Disease | Hosts: Kevin Lynch and Ken Hsu

April 28, 2016 | Hui Zheng, PhD, Professor, Baylor College of Medicine, Director, Huffington Center on Aging | Targeting Neuron-Glia Signaling and Autophagy-Lysosomal Pathway for Alzheimer’s Disease | Host: Julius Zhu

April 25, 2016 | Irina Bochkis, PhD, Senior Research Fellow (Instructor) at the Broad Institute of MIT and Harvard | Pioneer Factors, Nucleosomes, and Nuclear Lamina – What’s the Connection? | Host: Pharmacology Faculty Search Committee

April 21, 2016 | Ismail Syed, PhD, Postdoctoral Research Fellow , Beth Israel Deaconess Medical Center, Harvard Medical School | Impact of a Novel Class of Mammalian Lipids on Metabolic and Inflammatory Diseases | Host: Pharmacology Faculty Search Committee

April 14, 2016 | Christopher Dulla, PhD, Assistant Professor of Neuroscience, Tufts University School of Medicine | Control Your Excitement: Astrocyte Regulation of Glutamate Signaling in the Developing and Injured Brain | Host: Mark Beenhakker

March 31, 2016 | Murali Prakriya, PhD, Associate Professor in Pharmacology, Northwestern University School of Medicine Activation Mechanisms of Store-operated Channels | Host: Bimal Desai

March 25, 2016 | Janelle Weaver, Pharmacology PhD Candidate, Doug Bayliss’s Lab | University of Virginia Dissertation Defense | Pannexin 1 Channel Function and Regulation in Neuropathic Pain | Host: Doug Bayliss

March 10, 2016 | Jessica Cardin, PhD, Assistant Professor of Neurobiology, Yale School of Medicine | Flexible Function: Cortical Circuits in Health and Disease | Host: Julius Zhu

March 3, 2016 | Annette Dolphin, PhD, FMedSci, Professor of Pharmacology, University College London | Neuronal Calcium Channel Function and Trafficking in Health and Disease | Host: Paula Barrett

February 25, 2016 | Dave Bridges, PhD, Assistant Professor, Department of Physiology, University of Tennessee Health Science Center | Effects of Obesity on Glucocorticoid-Mediated Metabolic Syndrome | Host: Thurl Harris

February 11, 2016 | Christopher Del Negro, PhD, Associate Professor and Chair of Applied Science, William & Mary | Cellular Origins of Breathing: Dbx1-derived Brainstem Interneurons Generate Inspiratory Rhythm and Motor Pattern | Host: Patrice Guyenet

Fall 2015

December 17, 2015 | Gilbert Kinsey, PharmD, PhD, Assistant Professor of Medicine, Nephrology Department, University of Virginia | Regulatory T-Cells in Acute Kidney Injury |  Host: Doug Bayliss

November 18, 2015 | Inaugural Joseph Larner Memorial Lecture in Pharmacology
3:15 PM: David Brautigan, PhD, F. Palmer Weber Medical Research Professor, Departments of Microbiology, Immunology, and Cancer Biology, and the Director, Center for Cell Signaling, University of Virginia | Unexpected Functions of an Ancient Protein Phosphatase
4:00 PM: Keynote Lecture by Morris J. Birnbaum, MD, PhD, Senior Vice President and Chief Scientific Officer of the Cardiovascular and Metabolic Disease (CVMED) Research Unit at Pfizer | Glycogen Synthesis and Beyond: The Complex Regulation of Hepatic Metabolism
Host: Douglas Bayliss

November 12, 2015 | Shawn Xu, PhD, Bernard W. Agranoff Collegiate Professor in the Life Sciences, Research Professor, Life Sciences Institute, Professor of Molecular & Integrative Physiology, University of Michigan | Sensory Receptors and Channels in C. elegans What Can’t a Worm Sense? | Host: Bimal Desai

October 22, 2015 | Matthew Wolf, MD, PhD, Associate Professor of Medicine, Division of Cardiology, University of Virginia | Drosophila as a Model of Human Cardiomyopathies | Host: Michelle Bland

October 8, 2015 | Jeffrey Smith, PhD, Senior Investigator, Cellular and Systems Neurobiology Section, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH) | Unravelling Brainstem Respiratory Circuits and the Origin of Breathing in Mammals | Host: Patrice Guyenet

September 10, 2015  | John Bushweller, PhD, Professor of Molecular Physiology & Biological Physics, Professor of Chemistry, University of Virginia | Drugging the Undruggable – Targeting Transcription Factors for Cancer Therapy | Host: Mark Beenhakker

July 24, 2015 | Samantha Adamson, Pharmacology PhD Candidate, Norbert Leitinger’s Lab | University of Virginia Dissertation Defense | Pannexin 1 and Adipose Tissue | Host: Norbert Leitinger

July 10, 2015 | Evan Taddeo, Pharmacology PhD Candidate, Kyle Hoehn’s Lab | University of Virginia Dissertation Defense | Discovery of Novel Mechanisms in Skeletal Muscle and Liver Underlying the Regulation of Blood Glucose Homeostasis | Host: Kyle Hoehn

July 9, 2015 | Marin Healy, Pharmacology PhD Candidate, Kyle Hoehn’s Lab | University of Virginia Dissertation Defense | Understanding the Role of Liver Acetyl-CoA Carboxylases in Normal Physiology, Metabolic Disease, and Liver Cancer | Host: Kyle Hoehn

Spring 2015

April 30, 2015 | Paul Buckmaster, DVM, PhD, Professor of Comparative Medicine and Neurology, Stanford School of Medicine | Sea Lions, Synaptic Reorganization, and Temporal Lobe Epilepsy | Host: Mark Beenhakker, Co-sponsored by the Department of Neurology

April 23, 2015 | Eve Marder, PhD, Professor of Biology, Brandeis University | Variability, Neuromodulation and Homeostasis in Neurons and Networks |
Host: Mark Beenhakker, Co-sponsored by the Neuroscience Graduate Program (NGP) and the Neuroscience Center of Excellence (NCOE)

April 10, 2015 | Garrett Mullins, Pharmacology PhD Candidate, Thurl Harris’s Lab | University of Virginia Dissertation Defense | Catecholamine-Induced Lipolysis Inhibits Glucose Uptake and Causes mTOR Complex Dissociation in Adipocytes | Host: Thurl Harris

April 9, 2015 | Joel Linden, PhD, Professor of Developmental Immunology, La Jolla Institute
12:00 PM: NKT Cells in Sickle Cell Anemia
4:00 PM: Adenosine Receptor Blockers for Tumor Immunotherapy
Host: Kevin Lynch

April 3, 2015 | Yasumasa Okada, MD, PhD, Murayama Medical Center, Tokyo, Japan | Active Roles of Astrocytes in Respiratory Control | Host: Patrice Guyenet

March 27, 2015 | James Adair, PhD, Professor, Material Science and Engineering, Biomedical Engineering, and Pharmacology, Director, Penn State Center on Nanomedicine and Materials, The Pennsylvania State University | Calcium Phosphosilicate: A New Way to Encapsulate and Deliver Chemotherapeutic Drugs and Imaging Agents | Host: Mark Kester, Co-sponsored by nanoSTAR Institute

March 26, 2015 | Judit Villen, PhD, Assistant Professor of Genome Sciences, University of Washington, Seattle | Systematic Interrogation of Signaling Networks Using Mass Spectrometry, Host: Thurl Harris

March 5, 2015  | Alison Barth, PhD, Professor of Biological Sciences, Carnegie Mellon University | MS-timescale Excitatory Synaptic Silencing by Somatostatin Neurons | Host: Julius Zhu

February 27, 2015  | Ku-Lung (Ken) Ksu, PhD, Assistant Professor of Chemistry, University of Virginia | Chemical Approaches for Basic and Translational Discoveries in Immunology | Host: Douglas Bayliss

February 26, 2015 | Li Gan, PhD, Associate Professor in Residence, Neurology, Associate Investigator, Gladstone Institute of Neurological Disease, University of California, San Francisco | The Balancing Act: Target Proteostasis and Innate Immunity in Neurodegeneration, Host: Julius Zhu

February 12, 2015 | Jill Siegfried, PhD, Professor & Head, Department of Pharmacology, University of Minnesota | The ERbeta – HER2 Connection in Lung Cancer | Host: John Lazo

January 22, 2015 | Alexandra Kadl, MD, Assistant Professor of Medicine, Division of Pulmonary and Critical Care Medicine, University of Virginia | Repair Mechanisms in Acute Lung Injury: The Role of Apoptotic Cell Removal, Host: Douglas Bayliss

Fall 2014

November 13, 2014 | George Dubyak, PhD, Professor of Physiology, Case Western Reserve University | Pyroptosis: A Caspase-1 Mediated Pathway of Inflammatory Cell Death, Host: Bimal Desai

November 3, 2014 | Roger J. Thompson, PhD, Assistant Professor, Departments of Cell Biology & Anatomy/Clinical Neurosciences, University of Calgary | A New NMDA Receptor Signaling Modality for Activation of Pannexin-1 During Stroke | Host: Brant Isakson, Co-sponsored by Department of Molecular Physiology & Biological Physics

October 23, 2014  | Richard Lewis, PhD, Professor and Chair of Molecular and Cellular Physiology, Stanford University School of Medicine Self-organization and Activation of Store-operated Calcium Channels in T Lymphocytes | Host: Bimal Desai

October 9, 2014  | Dan Raben, PhD, Professor of Biological Chemistry, Johns Hopkins University School of Medicine | Regulation and Neuronal Role of DGKtheta | Host: Thurl Harris

October 2, 2014 | Paul Kenney, PhD, Ward-Coleman Professor and Chair, Department of Pharmacology and System Therapeutics, Director, Experimental Therapeutics Institute, Icahn School of Medicine at Mount Sinai Hospital | Mechanisms of Nicotine Addiction | Host: Michael Scott

September 25, 2014 | Tin Tin Su, PhD, Professor, Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder | Genetic and Chemical Modulators of Radiation Sensitivity in Drosophila and Human Cancer Models | Host: Michelle Bland

September 23, 2014 | Brandon Kenwood, Pharmacology PhD Candidate, Kyle Hoehn’s Lab | University of Virginia Dissertation Defense | Characterization of a Novel Family of Mitochondrial Uncouplers | Host: Kyle Hoehn

August 28, 2014 | Sean Davies, PhD, Assistant Professor of Pharmacology, Vanderbilt University | The Yin and Yang of N-modified Phosphatidylethanolamines in Obesity | Host: Norbert Leitinger

July 15, 2014 | Emily Moser, Pharmacology PhD Candidate, Tom Braciale’s Lab | University of Virginia Dissertation Defense | Immune Mechanisms in Control of Lung Inflammation Injury after Influenza A Virus Infection | Host: Thurl Harris

July 14, 2014 | James Eaton, Pharmacology PhD Candidate, Thurl Harris’s Lab | University of Virginia Dissertation Defense | Mechanistic Insight into Phosphoregulation of the Lipin Family | Host: Thurl Harris

Spring 2014

May 8, 2014 | Diane Fingar, PhD, Associate Professor, Cell and Developmental Biology, University of Michigan | Direct Activation of mTORC1 Function by the Ikk-related Kinases TBK1 and IKKepsilon | Host: Thurl Harris

May 7, 2014 | Sarah Breevoort, Pharmacology PhD Candidate, Ira Schulman’s Lab | University of Virginia Dissertation Defense | The Role of Liver X Receptors in Reverse Cholesterol Transport and Atherosclerosis | Host: Ira Schulman

April 29, 2014 | Shai Silberberg, PhD, Program Director, Extramural Research Program, National Institutes of Health (NIH), National Institute of Neurological Disorders & Stroke (NINDS) | Enhancing the Reproducibility and Transparency of Research Findings: Ongoing Activities at NIH and Beyond | Host: Douglas Bayliss, Co-sponsored by the Neuroscience Graduate Program (NGP)

April 11, 2014 | Joel Elmquist, DVM, PhD, Professor of Internal Medicine and Pharmacology, Maclin Family Distinguished Professor in Medical Science, University of Texas Southwestern | Unraveling the CNS Pathways Regulating Energy Balance and Glucose Homeostasis | Host: Chien Li, Co-sponsored by the Neuroscience Graduate Program (NGP) and the Neuroscience Center of Excellence (NCOE)

April 4, 2014 | Eugene J. Barrett, MD, PhD, Professor of Medicine, Division of Endocrinology & Metabolism, University of Virginia School of Medicine | The Vascular Endothelium: A Key Interface between Insulin Secretion and Action | Host: Douglas Bayliss

March 27, 2014 | Robert K.S. Wong, PhD, Distinguished Professor and Chairman, Dept. of Physiology and Pharmacology, SUNY Downstate Medical Center | Glutamate Receptor Function in Epilepsy and Mental Retardation | Host: Julius Zhu

March 6, 2014 | Douglas G. Mashek, PhD,  Associate Professor, Department of Food Science and Nutrition, University of Minnesota | Liver, Lipid Droplets and Lipolysis: Linking Liver Metabolism to Metabolic Disease Etiology | Host: Kyle Hoehn

February 20, 2014 | Peter Butler, MD, Professor of Medicine, Chief, and Director, Larry Hillblom Islet Research Center, David Geffen School of Medicine, UCLA | The Role of Islet Liver Miscommunication in Diabetes | Host: Craig Nunemaker, Co-sponsored by the Division of Endocrinology and Metabolism

Fall 2013

November 14, 2013 | Michael Graziano, PhD, Drug Discovery and Development Professional; Former Executive Director, Cardiovascular Drug Discovery at Merck (Retired) | The Role of Niemann-Pick C1 Like 1 (NPC1L1) and Ezetimibe in Cholesterol Absorption | Host: Kevin Lynch

September 25, 2013 | P. Elyse Schauwecker, PhD, Associate Professor, Departments of Cell & Neurobiology and Pharmacology & Pharmaceutical Sciences, Keck School of Medicine and School of Pharmacy, University of Southern California | A Genetic Approach to Understanding Seizure-induced Excitotoxic Cell Death | Host: Ed Perez-Reyes, Co-sponsored by the Neuroscience Center of Excellence (NCOE)

September 12, 2013 | Eduardo R. Lazarowski, PhD, Research Associate Professor, Department of Medicine, Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center, University of North Carolina, Chapel Hill | Mechanisms and Consequences of Nucleotide | Host: Chien Li

September 5, 2013 | Karel Svoboda, PhD, Group Leader, Janelia Farm Research Campus, Howard Hughes Medical Institute (HHMI) | Lighting up the Circuits Underlying Tactile Decisions | Host: Mark Beenhakker, Co-sponsored by the Neuroscience Graduate Program (NGP)

September 4, 2013 | Dylan Kennedy, Pharmacology PhD Candidate, Mark Yeager’s Lab | University of Virginia Dissertation Defense | Molecular Mechanisms of Adenosine A1 Receptor Allosteric Enhancers | Host: Mark Yeager

August 29, 2013 | Karen Allen, PhD, Professor, Chemistry Department, Boston University | Specificity and Promiscuity in a Superfamily of Phosphatases | Host: Thurl Harris, Co-sponsored by the Department of Physiology

Spring 2013

June 17, 2013 | Mark Kester, PhD, G. Thomas Passananti Professor of Pharmacology; Director, Penn State Center for nanoMedicine and Materials; Co-Leader, Experimental Therapeutics, Penn State Hershey Cancer Institute; Penn State University College of Medicine | Nano “Solutions” for Drug Delivery | Host: John Lazo, Co-hosted by The Cancer Center | Penn State Research Foundation has licensed several of Dr. Kester’s nano “solutions” to Keystone Nano, Inc., PA. Dr. Kester is co-founder and Chief Medical Officer of Keystone Nano

May 2, 2013 | Michelle L. Bland, PhD, Senior Research Investigator Postdoctoral Fellow, Laboratory of Dr. Morris Birnbaum, Department of Medicine, Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania | Inflymmation, Insulin Resistance, and the Endocrine Control of Growth and Metabolism | Host: Pharmacology Faculty Search Committee

May 1, 2013 | Laura Jansen, MD, PhD, Associate Professor of Neurology, University of Virginia | Rationale for Age- and Pathology-Dependent Targeting of GABAergic Neurotransmission in Pediatric Epilepsy | Host: Doug Bayliss

April 25, 2013 | Stefan Feske, MD, Associate Professor of Pathology, Langone Medical Center, New York University | CRAC Channels in Immunity to Infection and Autoimmunity | Host: Bimal Desai

April 5, 2013 | Yale Goldman, MD, PhD, Professor of Physiology, Perelman School of Medicine, University of Pennsylvania | Molecular Motors in Singulo: Examining Nature’s NanoTransporters One by One | Host: Avril Somlyo, Co-hosted by the Departments of Physiology, Pharmacology, and Cell Biology

March 29, 2013 | Kevin Thorneloe, PhD, Senior Scientific Investigator, GlaxoSmithKline (GSK) | Insider Secrets to Securing a Job in “Big Pharma” | Host: PHAR 9004 Class

March 28, 2013 | Kevin Thorneloe, PhD, Senior Scientific Investigator, GlaxoSmithKline (GSK) | TRPV4 as a Novel Target for the Treatment of Heart Failure | Host: Bimal Desai

March 7, 2013 | Xinyu Zhao, PhD, Associate Professor of Neuroscience, University of Wisconsin | Stem Cell & Regenerative Medicine Center Post-transcriptional Regulation of Neural Stem Cells and Neurogenesis | Host: Julius Zhu

March 4, 2013 | Ling Qi, PhD, Assistant Professor, Division of Nutritional Sciences, Cornell University | OER Stress and Inflammation in Obesity and Diabetes | Host: Ira Schulman

February 28, 2013 | Carole Sztalryd, PhD, Associate Professor of Medicine, University of Maryland | Lipid Droplet Coat: An Adaptation to Cellular Energetic Needs | Host: Thurl Harris

February 20, 2013 | Jessica Geisler, Pharmacology PhD Candidate, Chien Li’s Lab | University of Virginia Dissertation Defense | Physiological Role of Vesicular Nucleotide Transporter in Regulating Pancreatic Beta Cell Function

February 14, 2013 | Scott Baraban, PhD, Professor in Residence of Neurological Surgery, William K. Bowes Jr. Endowed Chair in Neuroscience Research, University of California, San Francicso | Inhibition and Epilepsy: Genes, Synapses and Cell Transplantation | Host: Mark Beenhakker

February 12, 2013 | John Yu-Luen Lin, PhD, Senior Research Associate Postdoctoral Fellow, Laboratory of Dr. Roger Tsien, University of California, San Diego | Optical Controlling of Neural Activities: The Development of New Optogenetic Tools | Host: Pharmacology Faculty Search Committee

February 6, 2013 | Dudley Lamming, PhD, Senior Research Associate Postdoctoral Fellow, Laboratory of Dr. David Sabatini, Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology (MIT) | Separable Roles for mTORC1 and mTORC2 in the Extension of Mammalian Lifespan by Rapamycin | Host: Pharmacology Faculty Search Committee

January 24, 2013 | Zuoxin Wang, PhD, Professor of Psychology, Florida State University | A Rodent Model for Social Neuroscience | Host: Julius Zhu

January 15, 2013 | William Holland, PhD, Instructor, Department of Internal Medicine, Touchstone Diabetes Center, University of Texas Southwestern Medical Center | Adipose-Derived Factors Govern Glucose Homeostasis and Cell Survival via Changes in Sphingolipid Metabolism | Host: Pharmacology Faculty Search Committee

January 10, 2013 | Alexandra McPherron, PhD, Principal Investigator, National Institutes of Health (NIH), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Genetics of Development and Disease Branch Genetics of Development and Disease Branch | Metabolic Effects of Skeletal Muscle Hypertrophy | Host: Pharmacology Faculty Search Committee

January 3, 2013 | James Olzmann, PhD, Basic Life Science Research Associate, Department of Biology, Laboratory of Dr. Ron Kopito, Stanford University | Ubiquitin: At the Intersection of ER Protein Quality Control and Lipid Droplet Fat Storage | Host: Pharmacology Faculty Search Committee

Fall 2012

December 6, 2012 | Mark T. Nelson, PhD, Chair and University Distinguished Professor, Department of Pharmacology, The University of Vermont | Elementary Ca2+ Signals through Endothelial TRPV4 Channels Regulate Vascular Function | Host: Bimal Desai

November 8, 2012 | Amy Brooks-Kayal, MD, Professor of Pediatrics and Neurology, University of Colorado, Denver | GABA-A Receptor Regulation: Following Novel Pathways to New Therapies in Epilepsy | Host: Mark Beenhakker, Co-sponsored by the Department of Neurology

October 25, 2012 | Richard Simerly, PhD, Professor of Pediatrics, Biological Sciences, Neurobiology, Keck School of Medicine, University of Southern California; Director, Developmental Neuroscience Program; Deputy Director, Saban Research Institute, Children’s Hospital Los Angeles | Developmental Critical Periods and Hormonal Specification of Hypothalamic Neural Circuitry | Host: Chien Li

October 11, 2012 | René Jacobs, PhD, Assistant Professor, Metabolic and Cardiovasular Diseases Laboratory, University of Alberta | Understanding the Role of Phosphatidylcholine Biosynthesis in Metabolic Disorders | Host: Thurl Harris

September 27, 2012 | James Ntambi, PhD, Professor and Chair, Department of Nutritional Sciences, University of Wisconsin-Madison | The Role for Stearoyl-CoA Desaturase-1 in Obesity and Diabetes | Host: Kyle Hoehn

September 13, 2012 | William Klein, PhD, Professor of Neurobiology, Northwestern University | Connecting Alzheimer’s and Diabetes at the Molecular Level | Host: Joe Larner

August 30, 2012 | Stephen Rich, PhD, Director, Center for Public Health Genomics; Harrison Professor & Vice Chair, Dept. Public Health Sciences University of Virginia | Pharmacogenomic Impact of the Exome Sequencing Project | Host: John Lazo

Spring 2012

April 26, 2012 | Mary Laughlin, MD, Professor of Medicine, Hematology and Oncology, University of Virginia | Cellular and Molecular Mechanisms Underlying Umbilical Cord Blood Allogeneic Immune Tolerance | Host: Doug Bayliss

April 24, 2012 | Ling-Gang Wu, MD, PhD, Distinguished Lecturer, Senior Investigator, National Institutes of Health (NIH) | Control of Multiple Exo- and Endocytosis Modes at Synapses | Host: Slobodan Todorovic, Co-sponsored by the Neuroscience Graduate Program and the Department of Anesthesiology

April 12, 2012 | Deborah Muoio, PhD, Associate Professor, Depts of Medicine and Pharmacology & Cancer Biology, Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center | Targeted Metabolomics Links Muscle Insulin Resistance to Mitochondrial Stress | Host: Kyle Hoehn

March 29, 2012 | Joanna Sandilos, Pharmacology PhD Candidate, Doug Bayliss’s Lab | University of Virginia Dissertation Defense | Mechanisms for Pannexin 1 Channel Modulation & Gating | Host: Doug Bayliss

March 28, 2012 | Amanda Gellett, Pharmacology PhD Candidate, Kevin Lynch’s Lab | University of Virginia Dissertation Defense | Characterization of Lipid Kinases Involved in the Synthesis of Alkyl Lysophosphatidic Acid | Host: Kevin Lynch

March 22, 2012 | Yanping Zhang, PhD, Associate Professor, Department of Radiation Oncology and Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine | The Ribosomal Protein-Mdm2-p53 Signaling and Energy Metabolism | Host: Zhen Yan

February 14, 2012 | Massimo Scanziani, PhD, Distinguished Lecturer, Investigator and Vice Chair, HHMI and Section of Neurobiology, University of California, San Diego | Cortical Layer 6: A Volume Knob for Vision | Host: Julius Zhu, Co-sponsored by the Neuroscience Graduate Program

February 9, 2012 | Mary-Ann Bjornsti, PhD, Professor and Chair, Department of Pharmacology and Toxicology, University of Alabama at Birmingham | DNA Topoisomerase I: Lessons Learned from Single Molecule Experiments | Host: John Lazo

February 2, 2012 | Deanna L. Benson, PhD, Professor of Neuroscience, The Mount Sinai Medical Center | Making, Breaking, and Modifying Synapses | Host(s): Chae Seok Lim and the Zhu lab

Fall 2011

December 12, 2011 | Kathryn Barletta,  Pharmacology PhD Candidate, Joel Linden/Borna Mehrad’s Lab | University of Virginia Dissertation Defense | The Role of Adenosine A2B Receptors in the Leukocyte Response to Lung Injury and Infection

November 29, 2011 | Olivier Peyruchaud, PhD, Research Officer 1st class, INSERM (National Institute of Health and Medical Research), Health Research Federative Structure Lyon Est | The LPA/ATX Track in Bone Metastasis | Host: Kevin Lynch

November 16, 2011 | James Stone, MD, PhD, Assistant Professor of Radiology, University of Virginia | Neuroimaging Correlates of Repetitive Blast Exposure in Human Military Service Members | Host: Dean’s New Faculty Seminar Series

November 14, 2011 | Julia Halterman, Pharmacology PhD Candidate, Brian Wamhoff’s Lab | University of Virginia Dissertation Defense | NFAT5-dependent Regulation of Vascular Smooth Muscle Cell Phenotypic Modulation and Atherosclerosis | Host: Brian Wamhoff

November 10, 2011 | Catherine Kotz, PhD, Adjunct Associate Professor, University of Minnesota | Orexin Regulation of Physical Activity: Implications for Obesity | Host: Chien Li

November 3, 2011 | Silvia Penuela, PhD, Senior Research Associate, Department of Anatomy & Cell Biology, University of Western Ontario | Pannexins in Health and Disease | Host: Brant Isakson, Co-sponsored by the Robert M. Berne Cardiovascular Research Center (CVRC) and the Pannexin Interest Group (PIG)

October 27, 2011 | Yusuf Hannun, MD, Ralph F. Hirschmann Professor and Chairman, Biochemistry and Molecular Biology, Medical University of South Carolina | The Family of Sphingomyelinases in Cell Regulation | Host: Kevin Lynch

October 20, 2011 | Hui Li, PhD, Assistant Professor of Pathology, University of Virginia | Chimeric RNAs and Their Implications in Cancer | Host: Dean’s New Faculty Seminar Series

October 13, 2011 | Ming Guo, MD, PhD, Associate Professor of Neurology and Molecular & Medical Pharmacology, Brain Research Institute, University of California, Los Angeles (UCLA) David Geffen School of Medicine | Molecular Pathways to Parkinson’s and Alzheimer’s Disease | Host: Zhen Yan, Co-sponsored by the Robert M. Berne Cardiovascular Research Center (CVRC)

September 22, 2011 | Craig Nunemaker, PhD, Assistant Professor of Medicine, Endocrinology and Metabolism, University of Virginia | Low-grade Systemic Inflammation and the Decline of the Beta-cell in Type 2 Diabetes | Host: Douglas Bayliss

September 15, 2011 | Kyle Hoehn, PhD, Assistant Professor of Pharmacology, University of Virginia | Multiple Insulin Resistnce Pathways Converge at Mitochondria | Host: Dean’s New Faculty Seminar Series

September 8, 2011 | Keith Baker, PhD, Assistant Professor, Biochemistry and Molecular Biology, Virginia Commonwealth University (VCU) | Orchestrating Transcriptional Programs to Shift Metabolism: How the Fly Fuels Developmental Growth and Adapts to Hypoxia | Host: Thurl Harris

August 25, 2011 | Katherine Roche, PhD, Senior Investigator, Porter Neuroscience Research Center, National Institutes of Health (NIH) | Molecular Mechanisms Regulating Excitatory Synapses | Host: Julius Zhu

July 15, 2011 | Perry Kennedy, Pharmacology PhD Candidate, Kevin Lynch’s Lab | University of Virginia Dissertation Defense | Pharmacokinetic and Pharmacodynamic Characterization of a Sphingosine 1-phosphate Receptor Antagonist Prodrug | Host: Kevin Lynch

Spring 2011

May 26, 2011 | Elizabeth Sharlow, PhD, Associate Professor of Research in Pharmacology, University of Virginia | A Tale of Two Screens | Host: Doug Bayliss

April 28, 2011 | Laurie Goodyear, PhD, Associate Professor of Medicine, Harvard Medical School, Senior Investigator and Head, Section on Metabolism, Joslin Diabetes Center | Brown Adipose Tissue Regulation of Metabolism | Host: Zhen Yan

April 14-15, 2011 | Larner Symposium | Signaling and Disease in the 21st Century
Alfred Gilman (Cancer Prevention Res Inst Texas) – Opening remarks
Ronald Evans (Salk Institute) – Nuclear Hormone Receptors & Transcription
Bruce Spiegelman (Harvard Med) – Nuclear Receptors: Linking Obesity & Diabetes
Alan Saltiel (Univ Michigan) – Insulin Signaling & Membrane Transport
Michael Czech (U Mass) – Diabetes and Inflammation
Lewis Cantley (Harvard Med) – PI3 Kinases in Cancer
Joan Massague (Memorial Sloan-Kettering) – Signaling in Metastasis
Sarah Spiegel (Med Coll Virginia.) – Lipid Signaling in Disease
Jeffrey Friedman (Rockefeller Univ) – Neuronal Control of Appetite & Obesity
Joseph Larner – Reflections Past & Present
Ferid Murad (George Washington Univ) – Closing remarks

April 13, 2011 | Larry Gold, PhD, Professor of Molecular, Cellular, and Developmental Biology, University of Colorado | Biomarkers and Personalized Medicine: Research and Diagnostics | Host: Molecular Medicine Students

March 30, 2011 | Brooks Brodrick, Pharmacology PhD Candidate, Steve Cohn’s Lab | University of Virginia Dissertation Defense Seminar | Implications of Fibroblast Growth Factor Receptor-3 Signaling in Intestinal Epithelial Cells | Host: Steve Cohn

March 24, 2011 | Wen-Cheng Xiong, MD, PhD, Institute of Molecular Medicine and Genetics, Medical College of Georgia | Neogenin Signaling in Chondrogenesis, Iron Homeostasis, and Neurogenesis | Host: Julius Zhu

March 17, 2011 | Traci Czyzyk, PhD, Research Scientist, Psychological & Brain Sciences, Indiana University | Myelin Protein Zero-Like 3: A Novel Protein That Controls Energy Balance in Mice | Host: Pharmacology Faculty Search Committee

March 3, 2011 | Mark Beenhakker, PhD, Postdoctoral Research Fellow, Department of Neurology and Nuerological Sciences, Stanford University | Gaining Access to a Vast Pool of Extrasynaptic GABAB Receptors: How Control of Neurotransmitter Spillover Regulates Neural Output | Host: Pharmacology Faculty Search Committee

March 1, 2011 | Joshua Singer, PhD,  Assistant Professor of Ophthalmology and Physiology, Northwestern University | Synaptic Mechanisms Underlying Circuit Function in the Retina | Host: Doug Bayliss, Co-sponsored by the Neuroscience Graduate Program (NGP)

February 24, 2011 | Alfred Merrill, PhD, Professor and Smithgall Institute Chair, Molecular Cell Biology, School of Biology & the Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology  | Sphingolipid Biology in the ‘omics’ Era: The Joys and Challenges of Structural Diversity | Host: Kevin Lynch

February 23, 2011 | Bimal Desai, PhD, Instructor, Department of Cardiovascular Research, Harvard Medical School | Function and Regulation of TRPM7: A TRP Channel for Cell Fate Decisions | Host: Pharmacology Faculty Search Committee

February 10, 2011 | Vishal Gohil, PhD, Instructor in Medicine, Mootha Laboratory, Center for Human Genetic Research, Harvard University Medical School, Massachusetts General Hospital | Nutrient Sensitized Screening to Understand Mitochondrial Energy Metabolism | Host: Pharmacology Faculty Search Committee

February 9, 2011 | Johannes Hell, PhD, Professor of Pharmacology, University of California, Davis | CaMKII Binding in GluN2B is Important for LTP and Memory Consolidation | Host: Julius Zhu

February 3, 2011 | Michael Lawrence, PhD, Instructor of Pharmacology, University of Texas, Southwestern Medical Center | Calcineurin/NFAT and MAPK Regulation of Islet Cell Function and Differentiation | Host: Pharmacology Faculty Search Committee

Fall 2010

December 2, 2010 | John Hepler, PhD, Professor of Pharmacology, Emory University  | RGS14 As an Integrator of G Protein and MAPkinase Signaling Important for Hippocampal Synaptic Plasticity and Learning | Host: James Garrison

November 30, 2010 | Yang Dan, PhD, Howard Hughes Investigator and Professor of Neurobiology, University of California, Berkeley | Cholinergic Modulation of Visual Processing and Brain State | Host: Julius Zhu

November 12, 2010 | Yu-Hsin “Eva” Chiu, Ph.D. Candidate, Department of Biology & Biochemistry, University of Houston | Regulatory Mechanisms of BKCa Channel Trafficking: The Role of COOH-terminal Motifs in Alternative Splice Variants | Host: Doug Bayliss (Bayliss Lab Postdoctoral Candidate Seminar)

November 11, 2010 | Chi-Wing Chow, PhD, Associate Professor of Molecular Pharmacology, Albert Einstein College of Medicine | Signaling Crosstalk Between Calcineurin Phosphatase and cAMP Specific Phosphodiesterases – Implications for Post-transplantation Metabolic Complications | Host: Thurl Harris

October 29, 2010 | Reiesha Robbins, Pharmacology PhD Candidate, Raghu Mirmira’s Lab | University of Virginia Dissertation Defense Seminar | Mechanisms of Islet Dysfunction in Type 2 Diabetes

October 29, 2010 | Sheng Wang, Research Associate, Department of Neuroscience, School of Medicine, Case Western Reserve University | Nitric Oxide Potentiates GABAergic Transmission in the Nucleus Tractus Solitarii | Host: Doug Bayliss (Bayliss Lab Postdoctoral Candidate Seminar)

September 23, 2010 | Alison Roland. Pharmacology PhD Candidate, Sue Moenter’s Lab | University of Virginia Dissertation Defense Seminar | Metabolic Regulation of Fertility: An Emerging Role for AMP-activated Protein Kinase in the Control of Gonadotropin-releasing Hormone Neuron Function | Host: Sue Moenter

September 21, 2010 | Li Zhang, PhD, Associate Professor of Physiology & Biophysics, University of Southern California | Synaptic Circuitry Mechanism Underlying Functional Development of Auditory Cortex | Host(s): Guangfu Wag (Julius Zhu’s lab), Co-sponsored by the Neuroscience Graduate Program (NGP)

September 17, 2010 | Faraaz Chekeni, Pharmacology PhD Candidate, Kodi Ravichandran’s Lab | University of Virginia Dissertation Defense Seminar | Pannexin 1 Channels Regulate “Find-Me” Signal Release and Membrane Permeability During Apoptosis | Host: Kodi Ravichandran

September 9, 2010 | Carrie Haskell-Luevano, PhD, Professor of Pharmacodynamics, University of Florida | The Melanocortin Obesity Syndrome: Feeding to Voluntary Exercise | Host: Chien Li

August 26, 2010 | Harini Bagavant, MBBS, PhD, Assistant Professor of Nephrology, University of Virginia | Autoimmunity and Hyperlipidemia in Pathogenesis of Glomerular Disease | Host: Douglas Bayliss

July 13, 2010 | Weiping Han, PhD, Head, Lab of Metabolic Medicine, Singapore Bioimaging Consortium | Islet Hormone Secretion Regulation & Diabetes | Host: Zhen Yan

June 23, 2010 | Michal Fortuna, Pharmacology PhD Candidate, Patrice Guyenet’s Lab | University of Virginia Dissertation Defense Seminar | Role of the RTN Neurons in the Control of Breathing | Host: Patrice Guyenet

Spring 2010

May 7, 2010 | Jeff Sturek, Pharmacology PhD Candidate, Catherine “Lynn” Hedrick’s Lab | University of Virginia Dissertation Defense Seminar | A Novel Role for ABCG1 in Pancreatic Beta Cell Function | Host: Catherine “Lynn” Hedrick

April 29, 2010 | Ji-fang Zhang, PhD, Associate Professor of Physiology, Thomas Jefferson University | Feeling Calcium: Role of a Novel Ca2+ Sensor in Regulation of Synaptic Vesicle Endocytosis by Ca2+ | Host: Julius Zhu

April 22, 2010 | Dwayne Godwin, PhD, Assistant Dean, Graduate School of Arts & Sciences, Wake Forest University School of Medicine | A Rising Tide of Excitability in Acquired Seizure Disorders | Host: Ed Perez-Reyes

April 21, 2010 | Shu Wang, Postdoctoral Associate, Department of Biomedical Sciences, Cornell University | A “Small” Difference Between Human and Rat TRPV1 (Capsaicin Receptor) | Host: Doug Bayliss (Bayliss Lab Postdoctoral Candidate Seminar)

April 8, 2010 | Kevin Grove, PhD, Associate Scientist in the Division of Neuroscience, Director of the Metabolic Disease Working Group, Director of the Obese NHP Resource, Oregon Health and Science University (OHSU) | Programming of Metabolic Systems: Impact of Maternal Health and Diet | Host: Chien Li

March 23, 2010 | Mark Shapiro, PhD, Associate Professor of Physiology, University of Texas Health Science Center at San Antonio Regulation of and Functional Role of M-type (KCNQ) Potassium Channels in Neurons | Host: Doug Bayliss, Co-hosted by the Neuroscience Graduate Program (NGP)

March 18, 2010 | Teresa Dunn, PhD, Professor and Chair, Department of Biochemistry and Molecular Biology, Uniformed Services University of the Health Sciences (USUHS) | Serine Palmitoyltransferase, New Subunits of the Rate-limiting Enzyme of Sphingolipid Synthesis, New Insights into Hereditary Sensory Neuropathy, HSAN1 | Host: Tom Sturgill

March 11, 2010 | Jiandie Lin, PhD, Assistant Professor, Department of Cell & Developmental Biology, University of Michigan | Integration of Clock and Metabolism Through PCG-1 Transcriptional Coactivators | Host: Zhen Yan, Co-hosted by the Cardiovascular Research Center (CVRC)

March 1, 2010 | Irena Ignatova-Todorova, PhD, Department of Internal Medicine, Yale University | The Role of Apolipoprotein AV in Insulin Sensitivity | Host: Ira Schulman (Schulman Lab Postdoctoral Candidate Seminar)

February 25, 2010 | Brenda Bloodgood, PhD, Postdoctoral Fellow, Michael Greenberg’s lab, Harvard Medical School | ChIP- and RNA-seq Reveal a Role for Neuropeptides in Activity-dependent Regulation of Inhibition | Host: Tom Sturgill

February 4, 2010 | Zhi-Yong Tan, PhD, Cardiovascular Center and Department of Internal Medicine, University of Iowa | Functional Expression of Acid-Sensing Ion Channels in Carotid Body Chemoreceptors of Normal and Pre-Hypertensive Rats | Host: Paula Barrett (Barrett Lab Postdoctoral Candidate Seminar)

January 21, 2010 | Timothy Jegla, PhD, Assistant Professor, Department of Cell Biology, The Scripps Research Institute | Deletion of the Potassium Channel Kv12.2 Causes Hippocampal Hyperexcitability and Epilepsy | Host: Doug Bayliss

January 8, 2010 | Laura Stephan, Pharmacology PhD Candidate, Catherine “Lynn” Hedrick’s Lab | University of Virginia Dissertation Defense Seminar | Role of the G2A Receptor and LXR Phosphorylation in Hepatic Cholesterol Homeostasis

Fall 2009

November 20, 2009 | Andrew Morris, PhD, Professor of Medicine and Molecular & Cellular Biochemistry, University of Kentucky, Cardiovascular Research Center | Regulation of Signaling and Metabolism by Lipid Phosphatases | Hosts: Kevin Lynch and Doug Bayliss

November 12, 2009 | Donald P. McDonnell, PhD, Glaxo-Wellcome Professor of Molecular Cancer Biology, Department of Pharmacology and Cancer Biology, Duke University Medical School | The Complexities of Nuclear Receptor-cofactor Interactions Provide Opportunities for Mechanism-based Approaches for Drug Discovery | Host: Ira Schulman

November 6, 2009 | Yun Li, PhD, Research Associate, Neurology, Johns Hopkins University | Astroglial Transporter and Motor Neuron Degeneration: Translational and Basic Scientific Studies | Host: Pharmacology Faculty Search Committee

October 22, 2009 | Umesh Deshmukh, PhD, Assistant Professor of Research, Medicine, Nephrology, University of Virginia School of Medicine | Activation of Innate Immune Responses and Development of Autoimmunity | Host: Doug Bayliss

October 22, 2009 | Allison Armstrong, Pharmacology PhD Candidate, Catherine “Lynn” Hedrick’s Lab | University of Virginia Dissertation Defense Seminar | An Emerging Role for Sterols in the Regulation of the Immune System | Host: Catherine “Lynn” Hedrick

October 8, 2009 | Joyce Repa, PhD, Assistant Professor of Physiology, University of Texas, Southwestern, Medical Center at Dallas | Targeting NPC Proteins to Alter Cholesterol Balance in Human Disease | Host: Ira Schulman

September 24, 2009 | Brendan D. Price, PhD, Assistant Professor of Radiation Oncology, Division of Genomic Stability and DNA Repair, Dana-Farber Cancer Institute, Harvard University | Mechanistic Links between DNA Repair, Tip60 and Histone Methylation Codes | Host: Tom Sturgill

September 17, 2009 | Rosalind Coleman, MD, Professor of Nutrition and Pediatrics, Department of Nutrition, University of North Carolina | Acyl-CoA Synthetase-1 Gives Fatty Acids Their Marching Orders | Host: Thurl Harris

September 10, 2009 | David D. Moore, PhD, Professor of Molecular and Cellular Biology, Baylor College of Medicine | Nuclear Receptors – Best for Diabetes? | Host: Ira Schulman

August 7, 2009 | Melissa Hatley Nagelin, Pharmacology PhD Candidate, Catherine “Lynn” Hedrick’s Lab | University of Virginia Dissertation Defense Seminar | Role of 12/15-lipoxygenase in Macrophage ATP-binding Cassette Transporter G1 Expression and Function | Host: Catherine “Lynn” Hedrick

July 27, 2009 | Garret Stuber, PhD, Associate Investigator, The Ernest Gallo Clinic and Research Center, Dept of Neurology, University of California, San Francisco | Dissecting the Neural Circuitry of Reward Learning and Decision Making | Host: Pharmacology Faculty Search Committee

July 20, 2009 | Michael Scott, PhD, Postdoctoral Fellow, Elmquist Lab, Center for Hypothalamic Research, Dept of Internal Medicine, University of Texas Southwestern Medical Center | Extra-Hypothalamic Actions of Leptin and Orexin | Host: Pharmacology Faculty Search Committee

July 16, 2009 | Steven Crone, PhD, Postdoctoral Fellow, Dept of Neurobiology, University of Chicago | A Molecular Genetic Approach to Investigate Motor Circuits and Behavior | Host: Pharmacology Faculty Search Committee

July 13, 2009 | Da-Ting Lin, PhD, Postdoctoral Fellow, Huganir Lab | Dept of Neuroscience, HHMI, Johns Hopkins University | Activity Dependent AMPA Receptor Insertion and Synaptic Plasticity | Host: Pharmacology Faculty Search Committee

Spring 2009

May 18, 2009 | Carmella Evans-Molina, MD, Pharmacology PhD Candidate, Raghu Mirmira’s Lab | University of Virginia Dissertation Defense Seminar | The Little Enging That Couldn’t: The Beta Cell in Type 2 Diabetes | Host: Raghu Mirmira

May 4, 2009 | John Lazo, PhD, Allegheny Foundation Professor of Pharmacology, Director, Drug Discovery Institute, Director, Fiske Drug Discovery Laboratory, Co-Director, Molecular Therapeutics/Drug Discovery Program, University of Pittsburgh Cancer Institute | Novel Regulators and Small Molecule Inhibitors of Dual Specificity Phosphatases | Host(s): Douglas Bayliss and Michael Weber

April 23, 2009 | Chih-Hao Lee, PhD, Assistant Professor, Genetics and Complex Diseases, Harvard University School of Public Health | Coordinated Regulation of Metabolic and Inflammatory Pathways by PPAR Delta | Host: Ira Schulman

April 10, 2009 | Sarah Blythe, Doctoral Candidate, Bevan Lab, Physiology Department, Northwestern University | Postsynaptic Mechanisms Underlying Burst Firing in Substantia Nigra Pars Compacta Neurons| Host: Douglas Bayliss (Bayliss Lab Postdoctoral Candidate Seminar)

April 9, 2009 | Tamas Balla, MD, PhD, Senior Investigator, NICHD, National Institutes of Health (NIH) | Studying Inositol Lipid-Calicium Signaling | Host: James Garrison

March 12, 2009 | Zhen Yan, PhD, Professor of Physiology & Biophysics, State University of New York (SUNY) at Buffalo | Dynamic Regulation of Synaptic Transmission by Neuromodulators in Prefrontal Cortex | Host: Julius Zhu

February 26, 2009 | Zhen Yan, PhD, Associate Professor of Cardiology, Director of the Center for Skeletal Muscle Research, Robert M. Berne Cardiovascular Research Center, University of Virginia | Mitophagy Mediates Mitochondrial Degeneration and Ectopic Lipid Accumulation in Insulin Resistance | Host: Doug Bayliss

February 17, 2009 | Karl Deisseroth, MD, PhD, Associate Professor of Bioengineering and Psychiatry, Stanford University | Optogenetics: Development and Application | Host: Doug Bayliss, Co-sponsored by the Neuroscience Graduate Program (NGP)

February 16, 2009 | Andrew J. Morris, PhD, Professor of Medicine and Molecular and Cellular Biochemistry, University of Kentucky College of Medicine | Blood Relatives:  Metabolism and Function of Bioactive Lysophospholipids in the Cardiovasculature | Host: Kevin Lynch

January 22, 2009 | Steven Thomas, MD, PhD, Associate Professor of Pharmacology, University of Pennsylvania | Monoamines, Memory, and Mouse PTSD | Hosts: Julius Zhu and Lei Zhang