Seminar Series

Please Note: Starting in the Fall 2016 semester, seminars are at 9:30 AM.

  • Upcoming Seminars

    • 13Sep

      Pharmacology Seminar by Susan Schwab

      Where: Pinn 1-17
      Hosted by Kevin Lynch, Susan R. Schwab is an Associate Professor in the Department of Pathology, Skirball Institute, NYU Langone Health, New York, NY Schwab Lab studies lymphocyte migration, with an emphasis on three questions: What determines how long a lymphocyte stays in a given location--surveying for antigens or fighting infection--before it moves on? How are the gradients that direct immune cell migration established? How do the trafficking requirements of normal and leukemic T cells differ, and can these differences be targeted therapeutically? Much of our focus has been on how the residence time of T cells in lymphoid organs is determined. We have established that a gradient of the signaling lipid sphingosine 1-phosphate (S1P) is required to guide T cells out of lymphoid organs. We have also identified many of the key cells and enzymes that control this gradient, and we have developed novel tools to map it. Future work will assess how S1P gradients are regulated during an immune response.

    • 27Sep

      Pharmacology Seminar by Amy Walker

      Where: PINN 1-17
      Hosted by Thurl Harris, Amy K. Walker, PhD, is an Associate Professor of Molecular Medicine, University of Massachusetts Medical School, Worcester, MA The Walker lab uses worms, cells and mice to study how metabolites like the methyl-donor SAM or the methylated phospholipid PC regulate gene expression, the activity of the lipogenic transcription factor SREBP-1 and how bacterial metabolites can affect lipid accumulation in multicellular animals.

    • 11Oct

      Pharmacology Seminar by Yanhua Huang

      Where: PINN 1-17
      Hosted by Julius Zhu, Yanhua Huang, PhD, is an Associate Professor of Psychiatry, University of Pittsburgh, Pittsburgh, PA Yanhua Huang, PhD has focused her research on neural plasticity within the reward circuitry of the brain. She studies molecular and cellular mechanisms underlying drug abuse and addiction and sleep-mediated regulation of reward-elicited behaviors. By studying neural plasticity in rodent models, she is working to characterize pathway-specific changes in the reward circuitry of the brain following sleep disturbances and identify molecular targets for new interventions for drug addiction, depression, and other related psychiatric disorders.

    • 25Oct

      Pharmacology Seminar by Steve Kliewer

      Where: PINN 1-17
      Hosted by Irina Bochkis, Steven Kliewer, PhD, is a Professor and Diana K. and Richard C. Strauss Distinguished Chair in Developmental Biology in Molecular Biology and Pharmacology, UT Southwestern Medical Center, Dallas, TX Dr. Kliewer runs a joint laboratory with Dr. David Mangelsdorf. Their research focuses on the roles of nuclear receptors and endocrine FGFs in regulating diverse aspects of physiology and pathophysiology, including metabolism and related diseases. Among their ongoing projects, they are studying how FGF19 and FGF21 regulate bile acid and energy homeostasis, respectively, and how the dafachronic acid receptor, DAF-12, regulates the infectious lifecycle of parasitic nematodes

    • 08Nov

      Pharmacology Seminar by Benjamin Turk

      Where: PINN 1-17
      Hosted by John Fu, Ben Turk, PhD, is an Associate Professor of Pharmacology, School of Medicine, Yale University, New Haven, CT Research interests: Deciphering mechanisms of substrate targeting by protein kinases The completion of the human genome a decade ago revealed more than 500 genes encoding protein kinases, and mass spectrometry based phosphoproteomics efforts have now cataloged over 100,000 sites of phosphorylation in mammalian cells. These studies have clearly outpaced our ability to understand signaling networks through analysis of individual kinases and their substrates: for the vast majority of the phosphorylation sites, the responsible kinase and functional significance are simply not known. My group studies basic mechanisms used by kinases to target specific substrates within the cell, with the idea of applying this knowledge to identify new kinase-substrate pairs on a proteomic scale. Kinases interact with their substrates through short sequence motifs found both at the site of phosphorylation and at distal sites. We develop methodology that allows for the rapid identification of these protein kinase recognition motifs. Using synthetic peptide arrays, we have recently conducted a biochemical screen to identify phosphorylation site motifs recognized by the entire set of kinases from budding yeast, and a similar screen...

    • 29Nov

      Pharmacology Seminar by Christopher Ford

      Where: PINN 1-17
      Hosted by Julius Zhu, Christopher Ford, PhD, is a Principal Investigator in the Department of Pharmacology, School of Medicine, University of Colorado, Denver, CO The Ford Lab examines the neuronal mechanisms by which G-protein coupled receptors (GPCRs) mediate synaptic transmission in the mesolimbic and nigrostriatal systems. Neuromodulators such as dopamine, acetylcholine and serotonin play key roles in controlling a variety of motivated behaviors including decision-making, action selection, motor skill learning, habit formation and reward processing. We use the combination of electrophysiology, 2-photon imaging, optogenetics and electrochemisty to study how the synaptic release of these transmitters becomes encoded within mesolimbic and nigrostriatal circuits through their GPCRs. By identifying the mechanisms regulating metobotropic transmission we aim to identify the disruptions in these system that are thought to underlie psychiatric disorders such as drug addiction and schizophrenia.

    • 28Feb

      Pharmacology Seminar by Edward Dennis

      Where: PINN 1-17
      Hosted by Ku-Lung(Ken) Hsu, Edward Dennis, PhD, is a Distinguished Professor of Pharmacology and Chemistry & Biochemistry, School of Medicine, University of California, San Diego, CA The Dennis laboratory is leading the national NIGMS LIPID MAPS Glue Grant Consortium which is developing LC/MS based lipidomics analysis to map the lipidome by detecting and quantizing the numerous molecular species of lipids in the murine macrophage. We are determining the lipid changes upon cell stimulation by various agonists such as TLR receptor agonists. Our laboratory is focused on identifying the known and discovering new fatty acids and eicosanoid metabolites (prostaglandins and leukotrienes) in these cells and using LC/MS to follow their production upon cell stimulation and determining lipid metabolite fluxes at the cellular level.

    • 07Mar

      Pharmacology Seminar by Savraj Grewal

      Where: PINN 1-17
      Hosted by Michelle Bland, Savraj Grewal is an Associate Professor in Biochemistry & Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada Grewal lab is a member of the Clark Smith Center, a Brain Tumor Research Program at the Arnie Charbonneau Cancer Institute in Calgary, Alberta. The lab are also members of the Department of Biochemistry and Molecular Biology at the University of Calgary. Research focus: Studying the control of growth Understanding how cells grow and divide is a fundamental problem in biology. During animal development the proper regulation of cell growth is essential for controlling organ and organism size. While in cancer, deregulated cell growth is often an early event in tumor formation. We use a combination of molecular and genetic approaches to study cell, tissue and body growth, using Drosophila as a model system.

    • 11Apr

      Pharmacology Seminar by Sayeepriyadarshini (Sayee) Anakk

      Where: Pinn 1-17
      Hosted by Irina Bochkis, Sayeepriyadarshini "Sayee" Anakk, is an Assistant Professor of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL The Annak Lab focuses on understanding liver metabolism in normal and diseased state. It's goal is to investigate how bile acids and nuclear receptors maintain metabolic homeostasis, and contribute to liver diseases, including cancer using cell-based systems and genetically engineered mouse models. Liver is a major organ that regulates metabolism of triglycerides, cholesterol, glucose, amino acids, heme, xenobiotics and many more substances. One of the salient features of the liver is to make bile! Bile acids are amphiphilic detergents synthesized in liver to facilitate absorption of dietary lipids. Biliary homeostasis is critical and defects/dysfunctions in this pathway lead to several liver diseases including liver cancer.

    • 25Apr

      Pharmacology Seminar by Nigel Pedersen

      Where: PINN 1-17
      Hosted by Steve Abbott, Nigel Pederson, PhD, is an Assistant Professor of Neurology, Emory University, Atlanta, GA. In the Pedersen Epilepsy and Systems Neuroscience Laboratory, we study the systems neuroscience of wakefulness and epilepsy in humans and animal models. There are two main streams of research. The first centers on the neurobiological basis of consciousness and the underlying wake-sustaining mechanisms upon which it depends (1-6); another group of projects examines brain networks in epileptic seizures, including the modulatory effects of sleep-wake circuits and networks through which seizures propagate. We study large-scale brain circuits underlying wakefulness and sleep. Using a variety of genetically encoded technologies in mice, we have recently described a new component of the brain circuit that maintains wakefulness, the supramammillary hypothalamus (3). This region exerts control over both the hippocampal network (important for certain kinds of memory formation) as well as the wake network and cerebral cortex. A unique and interesting feature of this neuronal group is the presence of a subpopulation of neurons that we described to release both inhibitory GABA and excitatory glutamate on to a key population of hippocampal neurons - dentate granule cells (3). These neurons are sparsely firing neurons that...