Seminar Series

Please Note: Starting in the Fall 2016 semester, seminars are at 9:30 AM.

  • Upcoming Seminars

    • 26May

      "Unraveling Insulin Transport Across the Brain Endothelium"- Pharmacology Dissertation Defense by Sarah Gray

      Where: Mckim Hall, Sandridge Auditorium
      Ms. Sarah Gray is a Pharmacology PhD Candidate in Eugene Barrett's Lab

    • 31Aug

      Pharmacology Seminar by Sheila Collins

      Where: Pinn Hall 1-17
      Hosted by Thurl Harris, Sheila Collins is a Professor of the Integrative Metabolism Program, Sanford Burnham Prebys Medical Discovery Institute. Dr. Collins's laboratory is interested in the biochemical mechanisms that regulate body weight. Activation of the adrenaline receptors, specifically the members of the beta-adrenergic receptor (beta-AR) family, provides the major stimulus for the hydrolysis and release of stored lipids. They are also key drivers of a process called "nonshivering thermogenesis" in brown fat. Brown fat cells are specialized cells rich in mitochondria and largely defined by their ability to express the mitochondrial uncoupling protein UCP1, which allows the dissipation of the proton gradient in the inner mitochondrial membrane to yield heat at the expense of ATP production. By understanding the beta-ARs on fat cells, their signal transduction properties and how they are regulated, we hope to be able to find a way to increase energy expenditure in fat in the fight against obesity and the devastating diseases that accompany it, such as diabetes, cardiovascular disease and hypertension.

    • 14Sep

      Pharmacology Seminar by Jonathan Kagan

      Where: Pinn Hall 1-17
      Hosted by Bimal Desai, Jonathan Kagan, Phd, is an Associate Professor of Pediatrics, Harvard Medical School Research Focus Area: Signal transduction pathways of the immune system Ancient signaling pathways lie at the base of the initiation of immunity, serving to transmit signals from Pattern Recognition Receptors (PRRs) to trigger the activation of anti-microbial defenses. All PRRs, which evolved to detect potentially pathogenic microorganisms, operate by following two cellular rules: 1) these receptors must activate cytosolic signaling with extremely fast kinetics (within seconds of ligand binding) 2) these receptors must survey multiple cellular compartments, yet still recruit a common set of signaling proteins to each location. How does a signaling network develop that has properties of near immediate responsiveness, yet the flexibility to signal from multiple locations? While most research on immune signal transduction focuses on the effector functions of signaling proteins, we are interested in understanding how these proteins are organized in the cytosol to promote both rapid responses and the flexibility of signaling locale. Using the Toll-like Receptor (TLR) family of PRRs as a model, we seek to explain the operation of cytosolic signaling proteins that function in immune defense. TLRs promote the initiation of both...

    • 12Oct

      Pharmacology Seminar by John Huguenard

      Where: Pinn Hall 1-17
      Hosted by Mark Beenhakker, John Haguenard, Phd is a Professor of Neurology and Neurological Sciences, Standford University Lab Summary: We study mechanisms of neural circuit synchronization and oscillation, using a combination of methods, including neurophysiological, pharmacological, neuroanatomical, and computational. Neural oscillations are associated with a variety of behaviors including selective attention, exploration, sleep and epilepsy. One powerful method of analysis is dynamic clamp, which allows the experimenter to build hybrid circuits linking computational models with biological systems in real time. Representative publications: Bacci, A and Huguenard, J.R. (2005) Enhancement of spike precision by autaptic transmission in neocortical inhibitory interneurons. Neuron 49:119-130. ( Supplemental Information) Sohal, V.S and Huguenard, J.R. (2005) Inhibitory coupling specifically generates emergent gamma oscillations in diverse cell types. PNAS 102:18638-43. (Supplemental Information ) Deleuze, C. and Huguenard, J.R. (2006) Distinct electrical and chemical connectivity maps in the thalamic reticular nucleus: potential roles in synchronization and sensation. J Neurosci 26:8633-8645. Huguenard JR, McCormick DA (2007) Thalamic synchrony and dynamic regulation of global forebrain oscillations. Trends Neurosci. 30:350-6 Dulla,C. Tani, H. Okumoto, S., Frommer, W.B., Reimer, R.J. and...

    • 09Nov

      Pharmacology Seminar by Christophe Bernard

      Where: Pinn Hall 1-17
      Hosted by Mark Beenhakker, Christophe Bernard, PhD is Director of the Physiology & Physiopathology of Neuronal Networks Group(PhysioNet), Institut de Neurosciences des Systemes. After an initial training in theoretical physics and mathematics, he did a Ph.D. on "Theoretical and experimental analysis of cellular activity in the cerebellum". He then did a Post Doc in Southampton University with Howard Wheal on synaptic plasticity in an experimental model of Temporal Lobe Epilepsy. Since then, his activity has been focused on the mechanisms underlying the construction of an epileptic brain. He has been awarded with the Michael Prize in 2007. Focus of the Physiology & Physiopathology of Neuronal Networks Group (PhysioNet) that Dr. Bernard Leads: The principal objective is to understand how physiological and pathological behaviors emerge from the organization and the reorganization of the underlying neuronal architecture. The group's research is structured around five themes: 1. Cell/network dynamics and learning in physiological and pathological conditions (in epileptic patients, monkeys and rodents) 2. Mechanisms leading to the construction of an epileptic brain (in epileptic patients, monkeys and rodents) 3. Anatomo-functional organization of normal and epileptic networks (in epileptic patients, monkeys and rodents) ...

    • 30Nov

      Pharmacology Seminar by Zhiping Pang

      Where: Pinn Hall 1-17
      Hosted by Michael Scott, Zhiping Pang, PhD is an Assistant Professor and Principal Investigator, Neuroscience and Cell Biology, Child Health Institute of New Jersey, Rutgers-Robert Wood Johnson Medical School Mechanisms of synaptic regulation: From stem cell to the brain Dr. Pang's laboratory studies the neural basis of the regulation of feeding, satiety, metabolism and obesity. Studies may provide insights into the neural causes and consequences of childhood obesity. His lab also developed novel techniques for deriving neuronal cells from primary skin cells and pluripotent stem cells, providing novel opportunities to study the pathogenesis of neurological disorders, including pediatric developmental disorders and autism spectrum disorders.

    • 07Dec

      2017 Joseph Larner Memorial Lecture in Pharmacology by Daniel P. Kelley

      Where: 1st Floor PHCC (Auditorium
      A lectureship was established to honor the memory of Joseph Larner, who served as Professor and Chair of the Pharmacology Department for many years. During his time as Chair he recruited and mentored numerous successful faculty, including Al Gilman. He continued to be an inspiration to everyone who knew him, especially our graduate students, who were in awe of his energy and enthusiasm as he kept up his science and maintained an active departmental presence well into his 90s. In addition to honoring Dr. Larner's memory, the goal of this lectureship is to highlight exciting new advances in an area that held great interest for him: the pervasive role of metabolism/cell signaling in human disease. About this Year's Speaker: Hosted by Thurl Harris, Daniel P. Kelly, M.D is the Willard and Rhoda Ware Professor and Director at Penn Cardiovascular Institute, University of Pennsylvania. Dr. Kelly obtained his medical degree from the University of Illinois College of Medicine, residency training at Barnes Hospital in St. Louis, and postdoctoral and clinical cardiology training at Washington University School of Medicine. He joined the Washington University School of Medicine faculty in 1989 and rapidly moved up the ranks to Professor...

    • 12Apr

      Pharmacology Seminar by James Grannerman

      Where: Pinn Hall 1-17
      Hosted by Thurl Harris, James Grannerman, PhD is a Professor of Molecular Medicine and Genetics and Internal Medicine, Director, Center for Integrative Metabolic and Endocrine Research(CIMER), Wayne State University Research Focus: Adipose tissue cell and molecular biology, target identification and high through-put screening for novel obesity and diabetes therapeutics Recent Publications: Lee YH, Mottillo EP, Granneman JG. Adipose tissue plasticity from WAT to BAT and in between. Biochim Biophys Acta. 2014 Mar;1842(3):358-69. doi: 10.1016/j.bbadis.2013.05.011. Epub 2013 May 17. PubMed PMID: 23688783. Lee YH, Thacker RI, Hall BE, Kong R, Granneman JG. Exploring the activated adipogenic niche: interactions of macrophages and adipocyte progenitors. Cell Cycle. 2014 Jan 15;13(2):184-90. doi: 10.4161/cc.27647. Epub 2014 Jan 6. PubMed PMID: 24394850; PubMed Central PMCID: PMC3906235. Mottillo EP, Paul GM, Moore HP, Granneman JG. Use of fluorescence microscopy to probe intracellular lipolysis. Methods Enzymol. 2014;538:263-78. doi: 10.1016/B978-0-12-800280-3.00015-3. PubMed PMID: 24529444. Donato M, Xu Z, Tomoiaga A, Granneman JG, Mackenzie RG, Bao R, Than NG, Westfall PH, Romero R, Draghici S. Analysis and correction of crosstalk effects in pathway analysis. Genome Res. 2013 Nov;23(11):1885-93. doi: 10.1101/gr.153551.112. Epub 2013 Aug 9. PubMed PMID: 23934932; PubMed Central PMCID: PMC3814888. Lee YH, Petkova AP, Granneman JG. Identification of an adipogenic niche for...

    • 26Apr

      Pharmacology Seminar by Yiyang Gong

      Where: Pinn Hall 1-17
      Hosted by Julius Zhu, Yiyang Gong is an Associate Professor, Biomedical Engineering, Duke University Research Interests: Recording and understanding brain activity by developing novel combinations of optical microscopy and genetically encoded sensors. Using these technologies to dissect neural circuit function and investigate how neural activity drives complex behaviors. Lab focus: Understanding brain function using the combination of genetically encoded sensors and optical techniques. Using genetically encoded tools, we can target specific neuron types or specific projection pathways for recording or perturbation. Using optical microscopy, we can access individual neurons with high spatial and temporal accuracy. By employing and developing tools in both categories, we study brain circuitry by recording, perturbing, and controlling brain activity in various preparations.