Journal Club Presentation Archive

Spring 2021

April 27, 2021 |Andrew Heindel, Pharmacology Grad Student, Ken Hsu’s Lab| Paper Presented (unpublished work): Discovery of Functional Cysteine Sites in the Proteome using Purine-based Activity-based Probes |Independent Research Presentation

April 13, 2021 |Greg Busey, Pharmacology Grad Student, Bimal Desai’s Lab| Paper Presented: Dorsal Raphe Serotonin Neurons Mediate CO2-Induced Arousal from Sleep. Haleigh R. Smith, at el. The Journal of Neuroscience (2018)|Mentor: Stephen Abbott

April 06, 2021 |Caitlin Pavelec, Pharmacology Grad Student, Norbert Leitinger’s Lab| Paper Presented: Serotonin neurons in the dorsal raphe nucleus encode reward signals. Yi Li , et al . Nature Communications, 7:1053, DOI: 10.1038/ncomms10503 (2016)  |Mentor: Stephen Abbott

March 30, 2021 |Binita Rajbanshi, Pharmacology Grad Student, George Bloom’s Lab| Paper Presented: The serotonergic raphe promote sleep in zebrafish and mice. Oikonomou , et al . Neuron, 103(4):686-701 (2019) | Mentor: Stephen Abbott

March 23, 2021 |Sofia Gasperino, Microbiology Grad Student/PSTG, Kodi Ravichandran’s Lab| Paper Presented: Anatomically Defined and Functionally Distinct Dorsal Raphe Serotonin Sub-systems. Ren , et al . Cell, 175, 472-487, (2018) | Mentor: Stephen Abbott

March 16, 2021 |Elizabeth Gonye, Pharmacology Grad Student, Doug Bayliss’s Lab| Paper Presented: Behavioral state coding by molecularly defined paraventricular hypothalamic cell type ensembles. Xu , et al . Science, 370, 313(2020)| Independent Research Presentation

March 02, 2021 |Adam Borne, Pharmacology Grad Student, Ken Hsu’s Lab| Paper Presented (unpublished work): Developing Chemical Biology Pipelines to Advance Sulfur-Triazole Exchange (SuTEx) Chemistry | Independent Research Presentation

February 23, 2021 |Philip Seegren, Pharmacology Grad Student, Bimal Desai’s Lab| Paper Presented: Mitochondrial Ca2+ Signaling Is an Electrometabolic Switch to Fuel Phagosome Killing. Philip Seegren , et al . Cell Reports, 33: 108411(2020) | Independent Research Presentation

February 16, 2021 |Mitch Granade, Pharmacology Grad Student, Thurl Harris’s Lab| Paper Presented (unpublished work): The Adenosine Switch: Dynamic Regulation of Adipose Tissue in The Fasted vs. Fed State | Independent Research Presentation

Fall 2020

November 10, 2020 |Matthew Ritger, Pharmacology Grad Student, Mark Beenhakker’s Lab| Paper Presented: Arterial Baroreceptors Sense Blood Pressure through Decorated Aortic Claws. Soohong Min, et al . Cell Reports, 29, 2192-220 (2019) | Mentor: Mark Beenhakker

November 03, 2020 |Claire Ruddiman, Pharmacology Grad Student, Brant Isakson’s Lab| Paper Presented: Astrocytes monitor cerebral perfusion and control systemic circulation to maintain brain blood flow. Nephtali Marina , et al . Nature Communications, 11: 131(2020)| Mentor: Mark Beenhakker

October 27, 2020 |Catherine Doyle, Pharmacology Grad Student, Bimal Desai’s Lab| Paper Presented: HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation. Venkat Giri Magupalli, et al . Science, 369, (2020)| Mentor: Michael Scott

October 13, 2020 |Yuntian Guan, Pharmacology Grad Student, Zen Yan’s Lab| Paper Presented: A PKB-SPEG signaling nexus links insulin resistance with diabetic cardiomyopathy by regulating calcium homeostasis. Chao Quan, et al . Nature Communications, 11: 2186 (2020)| Mentor: Michael Scott

October 06, 2020 |Jessica Hatter, Pharmacology Grad Student, Michael Scott’s Lab| Paper Presented: Ghrelin Signaling Affects Feeding Behavior, Metabolism, and Memory through the Vagus Nerve. Elizabeth A. Davis, et al . Current Biology, 30, 1-9 (2020).| Mentor: Michael Scott

September 29, 2020 |Tatianna Coverdell, Pharmacology Grad Student, John Campbell’s Lab| Paper Presented: Identification of peripheral neural circuits that regulate heart rate using optogenetic and viral vector strategies. Pradeep S. Rajendran, et al . Nature  Communications, (10)1944 (2019)| Independent Research Presentation

September 22, 2020 |Scott Yeudall, Pharmacology Grad Student, Norbert Leitinger’s Lab| Paper Presented: Dichotomous engagement of HDAC3activity governs inflammatory responses. Hoang C.B. Nguyen, et al. Nature, 584, 286-290 (2020)  | Independent Research Presentation

September 15, 2020 |Motteo Ottolini, Pharmacology Grad Student, Swapnil Sonkusare’s Lab| Paper Presented: Local Peroxynitrite Impairs Endothelial TRPV4 Channels and Elevates Blood Pressure in Obesity. Matteo Ottolini, et al. Circulation, 141: 1318-1333 (2020) | Independent Research Presentation

Spring 2020

May 05, 2020 |Bimal Desai, PhD, Associate Professor of Pharmacology, UVA| Immunology of COVID-19, Part II| Special Journal Club Series: Discussing Topics Related to COVID-19

April 28, 2020 |Bimal Desai, PhD, Associate Professor of Pharmacology, UVA| Immunology of COVID-19| Special Journal Club Series: Discussing Topics Related to COVID-19

April 21, 2020 |Kevin Lynch, PhD, Professor of Pharmacology, UVA| The Rise of Small Molecule Anti-Viral Medicines| Special Journal Club Series: Discussing Topics Related to COVID-19

April 14, 2020 |Kevin Lynch, PhD, Professor of Pharmacology, UVA| Virology And The Advent of Molecular Biology| Special Journal Club Series: Discussing Topics Related to COVID-19

March 03, 2020 |Merci Best, Pharmacology Grad Student, George Bloom’s Lab| Paper Presented (unpublished work): Bidirectional Regulation Between Tau and the Axon Initial Segment in an Alzheimer’s Disease Model| Independent Research Presentation

February 25, 2020 |Anders Nelson, Pharmacology Grad Student,  Jeff Saucerman’s Lab| Paper Presented (unpublished work): Mapping MBNL Signaling Regulation of Cardiac Myofibroblast Activation| Independent Research Presentation

February 18, 2020 |Brady Barron, Pharmacology Grad Student,  Kodi Ravichandran’s Lab| Paper Presented: Macrophage Metabolism of Apoptic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury. Arif Yurdagul, et al. Cell Metabolism, 31: 1-16 (2020)|Independent Research Presentation

February 11, 2020 |Roberto Mendez, Chemistry Grad Student/PSTG,  Ken Hsu’s Lab| Paper Presented: The dTAG System for Immediate and Target Specific Protein Degradation. Behnam Nabet, et al. Nature Chemical Biology. 14: 431-441 (2018)|Independent Research Presentation

Fall 2019

December 03, 2019 |Elizabeth Gonye, Pharmacology Grad Student,  Douglas Bayliss Lab| Paper Presented: A cautionary tale for cancer drug development. Lin, et. al., Sci.Transl.Med (2019)|Mentor: Kevin Lynch

November 19, 2019 | Clint Upchurch, Pharmacology Grad Student,  Norbert Leitinger Lab| Paper Presented: Mammalian YRNAs are modified at discrete guanosine residues with N-glycans. Ryan A. Flynn, et. al. BioRxiv 787614; doi: https://doi.org/10.1101/787614.|Mentor: Kevin Lynch

November 12, 2019 | Andrew Heindel, Pharmacology Grad Student,  Ken Hsu Lab| Paper Presented: A mitochondrial proteome profile indicative of type 2 diabetes mellitus in skeletal muscles. Sehyun Chae, et. al. Experimental & Molecular Medicine,  50:129 (2018)|Mentor: Paula Barrett

November 05, 2019 | Philip Seegren, Pharmacology Grad Student,  Bimal Desai Lab| Paper Presented: Mitochondrial Ca2+ Uptake InducesCyclic AMP Generation in the Matrix and Modulates Organelle ATP Levels. Guilietta Di Benedetto, et. al. Cell Metabolism,  17: 965-975 (2013)|Mentor: Paula Barrett

October 29, 2019 | Adishesh Narahari, Pharmacology Grad Student,  Douglas Bayliss Lab| K-ATP Channels Drive the Powerhouse| Paper Presented: Identification of an ATP-Sensitive potassium channel in mitochondria. Angela Paggio, et. al. Nature 572: 609-628 (2019)|Mentor: Paula Barrett

October 22, 2019 | Mitch Granade, Pharmacology Grad Student,  Thurl Harris Lab| Paper Presented: Identification, Characterization and Applications of a Global Tyrosine Chemical Probe. Adam L Borne,  Jeffrey W. Brulet,  Heung Sik Hahm and Emmanuel K. Toroitich |Independent Research Presentation

October 08, 2019 | Adam Borne, Pharmacology Grad Student, Ken Hsu Lab| Paper Presented: Identification, Characterization and Applications of a Global Tyrosine Chemical Probe. Adam L Borne,  Jeffrey W. Brulet,  Heung Sik Hahm and Emmanuel K. Toroitich |Independent Research Presentation

October 01, 2019 | Brittany Martinez, Pharmacology Grad Student, Michelle Bland Lab| Paper Presented: Toll signaling in the Drosophila larval fat body shifts programs of anabolic lipid metabolism and dysregulates nutrient storage. Martínez, B.A., Hoyle, R.G., Yeudall, S., Leitinger, S., and Bland, M.L.| Independent Research Presentation

September 24, 2019 | Brandon Podyma, Neuroscience Grad Student/PSTG, Christopher Deppman Lab| Paper Presented: The p75 Neurotrophin Receptor Integrates Energy Homeostasis and Circadian Timing |Paper Presented: The p75 Neurotrophin Receptor in AgRP Neurons is Necessary for Homeostatic Feeding and Food Anticipation. Podyma B, Johnson DA, Sipe L, Remcho TP, Battin K, Liu Y, Yoon SO, Deppmann CD, Güler AD. In preparation| Independent Research Presentation

September 17, 2019 | Katelyn Ahern, Pharmacology Grad Student, Thurl Harris Lab| Paper Presented: A Novel Approach to Quantifying Oxidized Lipids by Targeted Mass Spectrometry |Paper Presented: Regioisomer-independent quantification of fatty acid oxidation products by HPLC-ESI-MS/MS analysis of sodium adducts. Ahern KW, Serbulea V, Wingrove CL, Palas ZT, Leitinger N, Harris TE. Scientific Reports (2019)| Independent Research Presentation