M. Murat Koseoglu, PhD
Lazo Lab, MR4 4084
Aberrant neuronal cell cycle re-entry precedes and mechanistically prompts most of the neuronal loss observed in Alzheimer’s disease (AD). At Lazo lab, we are using human IPS derived neurons to develop a high content screen to find pharmaceutically attractive small molecules that will inhibit aberrant neuronal cell cycle re-entry in AD.
Keyong Li, Ph.D.
Bayliss Lab, Pinn 5013
My current study is how central chemoreceptors modulate respiration when exposed to high CO2 or the pH changed in blood in development. Phox2b (+) neurons in Retrotrapezoid Nucleus (RTN) are intrinsically sensitive to pH and play a vital role in regulating respiration. My study is focusing on the developmental changes of their pH-sensitivity and excitability. Multiple techniques including patch clamp, PCR, immunohistochemistry, imaging are used to investigate the ion channels in RTN neurons which are contributing to the developmental changes from cellular level to molecular level. Finally, the identified ion channels will be tested in whole animal model using in vivo gene transfer. The goal is to illuminate the mechanisms of modulation neuronal excitability and of respiration in development.
Mohan C Manjegowda
Scott Lab, Pinn Hall, Rm 5050C
I hail from the foothills of the Western Ghats, India. Completed my bachelor’s degree in biotechnology from Visvesvaraya Technological University and Ph.D. from Dept. of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, India. My doctoral research was focused on understanding the expression regulation and significance of G-protein coupled estrogen receptor (GPER1) in breast cancer. My research interests are epigenetics, chromatin dynamics, and gene expression regulation.
The focus of my postdoctoral research is to understand the onset and development of fatty liver disease (hepatic steatosis). Excessive accumulation of fat in the hepatocytes is a characteristic feature of hepatic steatosis. The pathological condition is also associated with the wrinkled nuclear lamina and abnormal nuclear morphology. I am studying the significance of this wrinkled nuclear lamina on chromatin dynamics and gene expression regulation. Using a gene-therapy approach, I am exploring the possibilities of reverting the wrinkles of the nuclear lamina to develop a treatment strategy. Next-generation sequencing techniques such as ChIP-Seq, Hi-C, and RNA-Seq are some of the high-end techniques I use for my investigation.
Sudip Pandit, PhD
Zhu Lab, Pinn Hall 5025
I am mainly interested in identifying the cortical interneurons in layer 6 and their circuit. With the help octuple patch clamp recording, immunohistochemistry and neurolucida technique, we try to match the physiology and anatomy of the neurons. We classify the neurons based on various
George M.P.R. Souza, PhD
Guyenet Lab, Pinn Hall 5228
My research interest is related to neural control of breathing and blood pressure. We are investigating how neurons at the lower brainstem (retrotrapezoid nucleus and rostral ventrolateral medulla) regulate breathing, blood gases homeostasis, blood pressure and arousal. We use chemo- and optogenetic approaches in vivo to perform gain- or loss-of-function experiments in order to reveal the role of specific neuronal types in those physiological variables.
Zhu Lab, Pinn Hall 5025
I am interested in elucidating how the different neurotransmitters are regulated under physiological and pathological conditions. My current project mainly focuses on developing genetically encoded sensors to detect acetylcholine and serotonin (5-HT).