Primary Cell Organotypic Culture
Regulation of low-voltage activated T-type Ca2+ channel activity by kinases and heterotrimeric G-proteins and their roles in physiological responses.
Mechanisms of neuromodulation in central neurons
Circuit mechanisms of sleep and epilepsy
Ion channels and Ca2+-signaling in inflammation, immunity and tissue homeostasis
Neural control of blood pressure and respiration
Molecular mechanisms controlling insulin signaling and fat synthesis.
Investigating the origin of insulin resistance in skeletal muscle and adipose tissue
Chemical Biology, Lipid Biochemistry, Medicinal Chemistry, and Mass Spectrometry
Role of lipid oxidation products in inflammation and vascular immunology in atherosclerosis and diabetes
Chemical biology of sphingosine 1-phosphate
Exploring epilepsy circuits then preventing seizures using gene therapies. Developing drug-inducible genetic switches for insulin replacement gene therapies.
Regulation of transcription by nuclear hormone receptors, transcriptional control of metabolism and inflammation, small molecule approaches to drug discovery
Investigation of the neuronal circuits and epigenetic modifications involved in the control of food intake, impulsivity and novelty seeking behavior
Role of endogenous peptides in control of cardiorespiratory function
Molecular and Signaling Mechanisms of Skeletal Muscle Plasticity
Neural Circuits in Healthy and Diseased Brains
Other PSTG Faculty
Pathogenic mechanisms in Alzheimer's Disease and other neurodegenerative disorders
Cellular and molecular mechanisms of Neisserial pathogenesis
Elucidating and Understanding the Mechanisms Underlying Nervous System Development
Exploring new therapeutics avenues to treat Multiple Sclerosis.
Hematopathology and Understanding the Molecular Basis of Hematopoiesis and Leukemogenesis
Translating our discoveries in the microcirculation to tangible benefits in patients.
Systems-biology approaches to cancer biology and virology.
Immune System Regulation of Cardiometabolic Disease
Roles of complex signaling networks involved in the regulation of cardiovascular function and disease
Endosomal function and dysfunction in neurons. Development of the nervous system: cytoskeleton and membrane traffic in axon and dendrite growth.