Regulation of low-voltage activated T-type Ca2+ channel activity by kinases and heterotrimeric G-proteins and their roles in physiological responses.
Mechanisms of neuromodulation in central neurons
Circuit mechanisms of sleep and epilepsy
Molecular mechanisms linking innate immune and insulin signaling to control cell growth and metabolism
Epigenetic and genetic mechanisms underlying metabolic disease
Ion channels and Ca2+-signaling in inflammation, immunity and tissue homeostasis
Neural control of blood pressure and respiration
Molecular mechanisms controlling insulin signaling and fat synthesis.
Investigating the origin of insulin resistance in skeletal muscle and adipose tissue
Chemical Biology, Lipid Biochemistry, Medicinal Chemistry, and Mass Spectrometry
The mechanism of action of small molecules and the fundamental biological role of protein tyrosine phosphatases
Role of lipid oxidation products in inflammation and vascular immunology in atherosclerosis and diabetes
Chemical biology of sphingosine 1-phosphate
Exploring epilepsy circuits then preventing seizures using gene therapies. Developing drug-inducible genetic switches for insulin replacement gene therapies.
Regulation of transcription by nuclear hormone receptors, transcriptional control of metabolism and inflammation, small molecule approaches to drug discovery
Role of endogenous peptides in control of cardiorespiratory function
Molecular and Signaling Mechanisms of Skeletal Muscle Plasticity
Neural Circuits in Healthy and Diseased Brains
Other PSTG Faculty
Pathogenic mechanisms in Alzheimer's Disease and other neurodegenerative disorders
Drug Development Targeting Transcription Drivers in Cancer; Structure/Function Studies of Transcription Factor Drivers in Cancer
The Neurobiology of Energy Balance
Systems Genetics Approaches to Understand Cardiometabolic Traits
Cellular and molecular mechanisms of Neisserial pathogenesis
The Role of Diabetes in Cognitive Decline
Exploring new therapeutics avenues to treat Multiple Sclerosis.
Translating our discoveries in the microcirculation to tangible benefits in patients.
Immune System Regulation of Cardiometabolic Disease
Regulatory T Cell biology in Inflammatory and Autoimmune Diseases.
Identify the calcium signaling abnormalities that lead to vascular dysfunction and blood pressure elevation in cardiovascular disorders
Endosomal function and dysfunction in neurons. Development of the nervous system: cytoskeleton and membrane traffic in axon and dendrite growth.