Regulation of low-voltage activated T-type Ca2+ channel activity by kinases and heterotrimeric G-proteins and their roles in physiological responses.
Mechanisms of neuromodulation in central neurons
Circuit mechanisms of sleep and epilepsy
Molecular mechanisms linking inflammation and insulin signaling to control cell growth and metabolism
Epigenetic and genetic mechanisms underlying metabolic disease
Electrical signals in inflammation and immunity
Neural control of blood pressure and respiration
Molecular mechanisms controlling insulin signaling and fat synthesis.
Investigating the origin of insulin resistance in skeletal muscle and adipose tissue
Lipid Metabolism in Inflammation and Immunity
Pediatric Epilepsy, Human Brain Development, Inhibitory Neurotransmission
Acute Kidney Injury, Regulatory T Cells, Innate Immune Response
The mechanism of action of small molecules and the fundamental biological role of protein tyrosine phosphatases
Role of lipid oxidation products in inflammation and vascular immunology in atherosclerosis and diabetes
Chemical biology of sphingosine 1-phosphate
Exploring epilepsy circuits then preventing seizures using AAV-based gene therapies.
Immunological mechanisms of acute kidney injury and progressive kidney disease
Regulation of transcription by nuclear hormone receptors, transcriptional control of metabolism, atherosclerosis, Small molecule approaches to drug discovery
Investigation of the neuronal circuits and epigenetic modifications involved in the control of food and drug reward
Role of endogenous peptides in control of cardiorespiratory function
Molecular and Signaling Mechanisms of Skeletal Muscle Plasticity
Neural Circuits in Healthy and Diseased Brains
Other PSTG Faculty
Diabetes and Insulin Action
T Lymphocyte Responses To Virus Infection
Structural and Functional Basis for Oncogenesis; Targeted Drug Development; Structural Studies of Membrane Proteins
Regeneration and Developmental Biology of the Hearing and Balance Organs in the Vertebrate Ear.
Cellular and molecular mechanisms of Neisserial pathogenesis
Exploring new therapeutics avenues to cure Multiple Sclerosis.
Intercellular communication as it relates to blood pressure regulation
Neuroimmunology and glia biology in cognition, neurodevelopment and neurodegeneration
Atherosclerosis, Obesity, Diabetes
Epigenetic Control of Perivascular and Stem Cell Plasticity/Trans-Differentiation during Injury-Repair and in Disease
Apoptotic cell clearance mechanisms in health and disease
Hypothalamic Peptide and Steroid Regulation of Pituitary Gene Transcription; Estrogen Action in Neuroendocrine and Reproductive Tissues; Estrogen Action in Breast Cancer
Pharmacology and function of T-type (low-voltage-activated, LVA) calcium channels in sensory transmission.