Neurobiology of the autonomic nervous system and the homeostatic control of breathing
Regulation of low-voltage activated T-type Ca2+ channel activity by kinases and heterotrimeric G-proteins and their roles in physiological responses.
Mechanisms of neuromodulation in central neurons
Circuit mechanisms of sleep and epilepsy
Molecular mechanisms linking innate immune and insulin signaling to control cell growth and metabolism
Epigenetic and genetic mechanisms underlying metabolic disease
Calcium-dependent, membrane-binding proteins and mechanisms of exocytosis
Ion channels and Ca2+-signaling in inflammation, immunity and tissue homeostasis
Sphingolipids in ocular disease and cancer
Cell signaling of protein kinases in development and disease
Modulation of aldosterone production in health and disease.
Neural control of blood pressure and respiration
Molecular mechanisms controlling insulin signaling and fat synthesis.
Investigating the origin of insulin resistance in skeletal muscle and adipose tissue
Hematology and Oncology
The mechanism of action of small molecules and the fundamental biological role of protein tyrosine phosphatases
Role of lipid oxidation products in inflammation and vascular immunology in atherosclerosis and diabetes
Chemical biology of sphingosine 1-phosphate
Understanding the neural code underlying motivated behaviors like feeding, drinking, and social interaction, with a focus on how malfunction in associated brain areas are involved in diseases like addiction and eating disorders
Exploring epilepsy circuits then preventing seizures using gene therapies. Developing drug-inducible genetic switches for insulin replacement gene therapies.
Regulation of transcription by nuclear hormone receptors, transcriptional control of metabolism and inflammation, small molecule approaches to drug discovery
Exploiting chemical biology approaches to understand signaling pathways that are critical for parasite, neuronal and tumor cell viability
Neural Circuits in Healthy and Diseased Brains