Obesity and Metabolism
The ongoing epidemic of obesity and metabolic syndrome threatens to burden our healthcare system with unsustainable healthcare costs in the coming decades. We aim to understand and manipulate the molecular mechanisms that contribute to obesity and its associated diseases. This knowledge will contribute to novel pharmacological approaches to check the onset and progression of metabolic diseases.
Molecular mechanisms linking inflammation and insulin signaling to control cell growth and metabolism
Epigenetic and genetic mechanisms underlying metabolic disease
Molecular mechanisms controlling insulin signaling and fat synthesis.
Investigating the origin of insulin resistance in skeletal muscle and adipose tissue
Chemical Biology, Lipid Biochemistry, Medicinal Chemistry, and Mass Spectrometry
Regulation of transcription by nuclear hormone receptors, transcriptional control of metabolism, atherosclerosis, Small molecule approaches to drug discovery
Investigation of the neuronal circuits and epigenetic modifications involved in the control of food intake, impulsivity and novelty seeking behavior
Molecular and Signaling Mechanisms of Skeletal Muscle Plasticity
Other PSTG Faculty
Systems Genetics Approaches to Understand Cardiometabolic Traits
Atherosclerosis, Obesity, Diabetes