Regulation of low-voltage activated T-type Ca2+ channel activity by kinases and heterotrimeric G-proteins and their roles in physiological responses.
Mechanisms of neuromodulation in central neurons
Circuit mechanisms of sleep and epilepsy
Calcium-dependent, membrane-binding proteins and mechanisms of exocytosis
Ion channels and Ca2+-signaling in inflammation, immunity and tissue homeostasis
Signaling mechanism of protein kinases in development and disease
Molecular mechanisms controlling insulin signaling and fat synthesis.
Investigating the origin of insulin resistance in skeletal muscle and adipose tissue
Chemical Biology, Lipid Biochemistry, Medicinal Chemistry, and Mass Spectrometry
The mechanism of action of small molecules and the fundamental biological role of protein tyrosine phosphatases
Exploring epilepsy circuits then preventing seizures using gene therapies. Developing drug-inducible genetic switches for insulin replacement gene therapies.
Exploiting chemical biology approaches to understand signaling pathways that are critical for parasite, neuronal and tumor cell viability
Molecular and Signaling Mechanisms of Skeletal Muscle Plasticity
Neural Circuits in Healthy and Diseased Brains
Other PSTG Faculty
Genomic Instability in Cancer Cells; Noncoding RNAs in differentiation and cancer; Bioinformatics of cancer outcome
Systems-biology approaches to cancer biology and virology.
Structure-Function of Active Transporters
Roles of complex signaling networks involved in the regulation of cardiovascular function and disease
Endosomal function and dysfunction in neurons. Development of the nervous system: cytoskeleton and membrane traffic in axon and dendrite growth.