Stornetta, Ruth L.

Ruth Stornetta

Ruth L. Stornetta

Primary Appointment

Associate Professor of Research, Pharmacology

Contact Information

PO Box 800735
1340 Jefferson Park Ave., Pinn Hall, Room 5228
Charlottesville, VA 22908
Telephone: 434-982-3977
Fax: 434-982-3878
Email: rs3j@virginia.edu

Research Interests

Role of endogenous peptides in control of cardiorespiratory function

Research Description

My research interests have centered on understanding the biochemical, pharmacological, physiological and anatomical basis of the role of endogenous opiates, GABA and glycine in the control of cardiorespiratory function. I have explored the withdrawal phenomenon both for morphine and for clonidine and have investigated specifically how these phenomena impact cardiovascular control systems. I have recently undertaken a new line of research to explore the inhibitory control of sympathetic nerve outflows. The current projects include the use of the pseudorabies virus (PRV) to mark specific autonomic targets and thus label sympathetic preganglionic neurons (SPGNs) and the presympathetic neurons antecedent to SPGNs. The PRV will be combined with a variety of other markers to determine the pattern of presympathetic neurons in the spinal cord and brainstem and the putative transmitter contained in these presympathetic neurons. Specifically, I will use in situ hybridization with a riboprobe constructed from the GAD-67 clone as a marker for GABA. I will also use antibodies directed against tyrosine hydroxylase (TH) as a marker for catecholamine neurons. I hope this will lead to a better understanding of the control of sympathetic outflows both at the medullary and spinal levels.

Selected Publications