Assistant Professor, Molecular Physiology and Biological Physics
- Diploma, Biology, Technische Universität Darmstadt
- PhD, Cell Biology, Max Planck Institute for Cell Biology and Genetics
- Post Doc, Cell Biology/ Biophysics, Technische Universität Dresden, Medical Theoretical Center
480 Ray C. Hunt Drive
Charlottesville, Va 22903
Biology, Biophysics, Cancer Biology, Cell and Developmental Biology, Molecular Biology, Molecular Physiology and Biological Physics, Physiology, Structural Biology
Chromosome segregation and aneuploidy in meiosis and mitosis
All eukaryotic cells divide by assembling a microtubule-based spindle machinery that equally segregates chromosomes between daughter cells. The faithful segregation of chromosomes during cell division is essential as errors in this process have severe implications for development, health and survival of the organism. One major outcome of chromosome segregation errors in mitosis is tumor initiation and progression. Analysis of cancer cell karyotypes revealed that aneuploidy, an abnormal number of chromosomes, is an extremely common feature, with 70 – 95% of cancers from the most commonly affected organs being aneuploid. Aneuploidy is associated with poor patient prognosis, metastasis, and resistance to chemotherapeutics. Chromosome segregation errors during meiosis, are the leading cause of early pregnancy loss and infertility.
Our aim is to understand the key molecular and mechanical principles and mechanisms of spindle assembly and chromosome segregation in meiosis and mitosis. We address this by using a combination of cutting-edge imaging technologies, such as large-scale 3D electron tomography and spinning disc live-cell microscopy, as well CRISPR and other genetic tools in tissue culture cells, mouse Oocytes and C. elegans embryos.
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