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Our laboratory is interested in investigating how cellular processes govern proper metabolic function and how abnormal physiology leads to metabolic disease. In particular, we apply experimental and computational methods to identify genetic and epigenetic mechanisms   regulating metabolism. We are focusing on understanding how genome-wide chromatin changes, which include chromatin accessibility, nuclear localization and dynamics, and genome organization, lead to physiological dysfunction. Our laboratory utilizes functional genomics, chromatin biology, physiology, and transcriptional regulation in a comprehensive approach to decipher molecular mechanisms in mammalian models of human metabolic disease.

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