Keyong Li, Ph.D.

November 2, 2018 by

Keyong Li

Keyong Li, Ph.D.

Research Scientist
Bayliss Lab, Pinn 5013

email: kl4jd@virginia.edu
phone: 434-982-4466

2 or the pH changed in blood in development. Phox2b (+) neurons in Retrotrapezoid Nucleus (RTN) are intrinsically sensitive to pH and play a vital role in regulating respiration. My study is focusing on the developmental changes of their pH-sensitivity and excitability. Multiple techniques including patch clamp, PCR, immunohistochemistry, imaging are used to investigate the ion channels in RTN neurons which are contributing to the developmental changes from cellular level to molecular level. Finally, the identified ion channels will be tested in whole animal model using in vivo gene transfer. The goal is to illuminate the mechanisms of modulation neuronal excitability and of respiration in development.