Yingtang Shi, Ph.D.
Assistant Professor of Research
Email: ys6c at virginia dot edu
2/pH sensitivity of RTN neurons and CO2-regulated breathing (e.g., NALCN, TASK-2, GPR4). Later, I used single cell RNA-seq to characterize the expression profile for RTN neurons. This led directly to the discovery of Neuromedin B as a highly specific marker for RTN neurons. More recently, I found a striking birth-related upregulation of the peptide PACAP in mouse RTN neurons, and demonstrated that this neuropeptide and its related circuit stimulates breathing and protects neonatal mice from breathing disturbances. I am currently characterizing the roles of other neuropeptides and transcription factors in regulating RTN neuronal activity and their relevance to central respiratory diseases.