Keyong Li, Ph.D.

April 13, 2015 by School of Medicine Webmaster

Keyong Li, Ph.D.

Research Associate
Email: kl4jd at virginia dot edu
Phone: 434-982-4466

2/H+ and control breathing. My recent work shows that TRPM4, a calcium-activated cationic channel, along with L-type calcium channels and various potassium channels (Kv and M channels), mediates a large subthreshold membrane potential oscillation that drives RTN neuron activity and breathing in mice (Cell Reports: 108714, 2021). I am currently investigating: ① the contribution of astrocytes in RTN to CO2-induced breathing in mice; and ② an RTN neuronal potassium channel that may be downstream of GPR4, which acts together with TASK-2 channels to sense CO2/H+. I use multiple tools for these studies, including patch clamp electrophysiology, qPCR, molecular histochemistry, imaging, viral-mediated gene expression injection and plethysmography in genetic mouse models.